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Showing 1 to 13 of 13 for “"angioedema"”.
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Angioedema Ereditario: aspetti neurobiologici e strategie di coping
… is the base of pathology known as “Hereditary Angioedema” (HAE). This pathology involves the onset of acute attacks consisting of circumscribed edema of the mucous membranes and of the subcutaneous. An HAE attack can modify suddenly, deforming, the appearance of the patient who has the …
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Genetic and biochemical analysis of ACE inhibitor-induced angioedema in black and coloured South Africans
… adverse side effects such as life threatening angioedema (ACEi-AE) and persistent dry cough (ACEi-cough)
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
Angioedema is a swelling of the subcutaneous and submucosal tissues that can involve lips, face, neck, extremities and/or submucosal tissues of the oral cavity, larynx and intestine. Patients with angioedema can be clinically critical and require urgent clinical evaluation, especially when …
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Screening Of Natural Products For Their Effect On Kallikrein-Kinin System: Potential Implications In The Treatment Of Hereditary Angioedema
… in the development of pathological pain and angioedema. Increased plasma kallikrein levels are associated with hereditary angioedema (HAE) and myocardial infarction, whereby kallikrein amplifies the generation of activated factor XII (FXIIa) and bradykinin (BK) release from high molecular …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
Wilson’s disease, SAPHO syndrome and Hereditary angioedema are three rare disorders characterized by a wide spectrum of different clinical manifestations, which involve several organs and apparatus, making the diagnosis extremely difficult. In this study, the salivary proteome and peptidome of …
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Optimization of Signal-Detection Methods in Novel Databases: a Focus on Direct-Acting Antivirals
… associated with direct-acting antivirals (DAAs): angioedema, dysglycemia, and hepatic decompensation and hepatic failure. The risk of angioedema or dysglycemia while on DAA therapy was identified through post-market surveillance, and prior studies did not include these two outcomes and had mixed …
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Synthesis of activity-based protein profiling probes for malaria and hypertension disease models & potential novel ACE inhibitors with an attenuated zinc binding group
… by unpleasant side effects, such as cough and angioedema. In malaria, the parasites continuously develop resistance to anti-malarial drugs where the disease is endemic. There is therefore a need for continuous research into the application of new techniques as well as the design of new small …
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Identification and characterization of human plasma prekallikrein-prolylcarboxypeptidase interaction sites
… are deeply involved in human diseases such as angioedema, disseminated intravascular coagulation, acute respiratory distress syndrome and sepsis. Therefore, the identification of PRCP/PK binding sites, and PRCP cleavage sites on PK, may be of clinical significance which would aid drug design. …
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Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
… ARB group, and 1 patient of combination group. Angioedema was recorded in 1 patient of ARB group and 1 patient of combination group. In ACEI group, ARB group, and combination group, amount of proteinuria decreased to 52.6%, 76.7% and 52.5% of initial amount at 24 week after starting each drug. …
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Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure
… effect but a higher than expected incidence of angioedema in patients with hypertension or heart failure. GW660511X is another dual ACE/NEP inhibitor at an earlier stage in development. The pharmacodynamic profile of neither the ACE inhibitor activity nor the NEP inhibitor activity of GW 660511X …
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Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
… disease (AERD), aspirin-intolerant urticaria/angioedema (AIU), chronic rhinitis, and anaphylaxis. We studied two major aspirin hypersensitivity, AIA and AIAU in an association with prostanoids receptor CRTH2 and TBXA2R. The human CRTH2 gene (official name GPR44) encodes a G protein-coupled …
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Molekulare Ursachen des hereditären Angioödems
Mutationen im C1-Inhibitor(C1-INH)-Gen manifestieren sich in Form autosomal dominant vererbter Angioödeme (hereditäres Angioödem (HAE)), wobei zwei Typen unterschieden werden. Während der HAE-Typ I mit einer Häufigkeit von 85% auftritt und durch erniedrigte C1-INH-Plasmaspiegel mit daraus …
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Effector Cells and Mechanisms in Chronic Spontaneous Urticaria
… urticaria (CSU) is characterised by weals, angioedema, or both, which occur for six weeks or more. Itchy, red and raised weals in CSU are thought to occur as a result of skin mast cell activation, local vasodilatation and increased vascular permeability which are the cardinal features of the …