Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"anergy"”.
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
… While both clonal deletion and apparent anergy have been described in response to superantigens, it has not been clear whether true anergy occurs, or whether the most reactive T cells are selectively deleted, leaving less reactive clones. To address this question, the response of an …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… by this route are well documented to induce anergy in NKT cells. Anergy is defined as the deficiency in NKT proliferation and cytokine production, including IL-4 and IFNγ. However, our studies have shown that two doses of α-GalCer administered intranasally by the intranasal route leads to …
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Transcription, Editing, and Switching of Antibody Genes
… were shown to be silenced by deletion, anergy, and receptor editing. While anergy and deletion physically eliminate the autoreactive clone, receptor editing salvages it by replacing its immunoglobulin receptor through ongoing V(D)J recombination. Once a functional non-self -reactive …
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Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation
… Finally, we demonstrate that the in vitro anergy is partially dependent on Foxp3+ cells whereas the in vivo anergy is not. In paper II, bone marrow-derived dendritic cells from IFN-β-/- mice were used to study the role of IFN-β in TLR2-mediated induction of iNOS. We demonstrate that the …
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Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… cells and comparison with other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced …
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Enhancement of the An1 Population by BAFF: Potential Role in Autoimmune Disease
… stimulation results in the induction of B cell anergy, both in vitro and in vivo. The induction of anergy in B cells in response to stimulation through the antigen receptor may provide a mechanism by which autoreactive cells can evade deletion. Ultimately, the presence of these anergic B cells …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… where a single dose of α-GalCer leads to anergy of responding NKT cells and thus hinders delivery of booster immunizations, we demonstrated that administration of multiple doses of α-GalCer by the intranasal route affords repeated activation of NKT cells and the induction of broad systemic …
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Visualizing Dendritic Cells In Vivo
… and with early antigenspecific arrest; T cell anergy was induced by all ligands that activated T cells, and was independent of T cell proliferation, Ca<sup>2+</sup> flux, and early arrest in vivo. We further examined the in vivo dynamics of germinal center reactions, and observed that germinal …
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B Cell Signaling and Bioinformatics: Revealing Components of the MHC Class II Antigen Processing and Presentation Pathway
… differentiation, activation, effecter function, anergy, and/or apoptosis. Gene expression microarrays are used to determine expression levels of a large number (tens of thousands) of genes simultaneously, resulting in a gene expression profile of the experimental sample. Microarray data must be …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… survival, proliferation, differentiation, death, anergy, and receptor editing may occur in response to BCR stimulation. A variety of factors, including signal strength and duration, cytokine presence, and co-stimulation determine the ultimate B cell fate. In this thesis, the roles Foxo …
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… cells and alloreactive NK cells induces NK cell anergy by enhancing the internalization and degradation of DNAM-1, a process significantly linked to the activation of the Cbl protein in alloreactive NK cells. Next, we aim to develop off-the-shelf CAR-T cells to translate this approach into human …
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A study of invariant NKT cell biology in health and disease
… novel compounds that were able to reduce iNKT anergy after initial activation. Finally we showed that these functional differences were modified by CD1d affinity and the nature of the antigen presenting cell, co existent cytokines and donor phenotype. Lastly, we applied our iNKT investigative …
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An investigation of T cell dysregulation in B-cell chronic lymphocytic leukaemia
… the results suggest a functional state of anergy in these T cells. This anergic state may contribute to the pathogenesis of B-CLL and its related phenomena of immunosuppression and autoimmunity. This was further reflected in the results of the T cell functional studies and reduced IL-2 …
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The Role of Transitional B cells in Kidney Transplantation Tolerance
… pathway, suggesting a certain degree of anergy or responsiveness by these cells. Donor- specific assays revealed that B cells from tolerant patients were inefficient to recognise donor-antigens, compared to B cells from chronic rejector. This impairment prevented the triggering of the Th1 …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… on an antigen-presenting cell (APC). Clonal anergy, one of the proposed mechanisms of peripheral tolerance, describes a state of long lasting unresponsiveness to antigen in the T cell. Such anergy is induced when the TcR is ligated in the absence of co-stimulation and can be evidenced, upon …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… due to the induction of donor PBMC apoptosis, anergy or T regulatory cells in this model; but likely due to the inhibition of donor CD4+ T cell proliferation and the significant reduction in systemic human TNFα. These findings contribute to a broader understanding of immune regulation by MSC …
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Programmed death-1 regulates islet-specific lymphocytes in type 1 diabetes
… surprisingly, PD-1 blockade did not override the anergy program. These findings suggested that the differentiation state of the CD4+ T cell pre-determine its susceptibility to PD-1 blockade. Autoantibody production is a hallmark of autoimmunity, and has also been reported in patients treated with …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
… in transgenic T cells, either by deletion, anergy or the induction of regulatory T cells. We wanted to examine whether delivery of autoantigens to DCs using this approach, could be used to tolerize autoreactive polyclonal T cells, thereby preventing autoimmunity in mouse models. We succeeded …
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Immune modulation mechanisms of porcine circovirus type 2
… death ligand-1 (PD-1) axis in porcine lymphocyte anergy, apoptosis, and the induction of Tregs. Lymphocyte populations with normal PD-1 expression had significantly higher percentages of anergic and apoptotic lymphocytes, and CD4+CD25HighFoxP3+ Tregs when compared to a PD-1 deficient lymphocyte …
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… while overexpression leads to immunological anergy. In this dissertation we report a previously unknown regulatory role of PD-1 that leads to inhibition of protective immunity. PD-1 deficiency promotes the production of the immunosuppressive cytokine interleukin-10 (IL-10). Enhanced IL-10 …
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