Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"androgen-deprivation therapy"”.
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Self-reported Exercise and Risk of Osteoporosis in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
… stimulated to grow in response to testosterone. Androgen deprivation therapy (ADT) leads to chemical castration and suppression of prostate cancer cell production. Testosterone levels less then 300ng/ml decreases bone mineral density and could result in osteoporosis. Studies have shown that …
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DOES STRENGTH TRAINING IMPROVE MUSCULOSKELETAL HEALTH AND BODY COMPOSITION IN BLACK MEN WITH PROSTATE CANCER ON ANDROGEN DEPRIVATION THERAPY?
… previous studies. PCa is commonly treated using androgen deprivation therapy (ADT). However, ADT induces numerous adverse side effects, including loss of muscle mass, strength, power, and physical function with concomitant increases in fat mass, fatigue, and bone fractures. Because strength …
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Investigating a novel combination treatment of androgen deprivation therapy, pelvic external beam radiotherapy and radium-223 dichloride in the management of hormone sensitive prostate cancer metastatic to bone
… for whichthe mainstay of treatment consists of androgen deprivation therapy (ADT).Recently a number of treatments added to ADT have been shown to extend survivalin these patients including docetaxel and abiraterone as well as external beamradiotherapy (EBRT) to prostate (in low volume disease). …
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Effects of pelvic 3D-CRT versus IMRT radiation therapy on circulating pro-inflammatory cytokines in high risk Prostate Cancer patients
… study examined the effects of pelvic radiation therapy on the levels of circulating pro-inflammatory cytokines (cPIC) in high-risk prostate cancer patients, who received pelvic radiation therapy delivered either by 3-dimensional radiation therapy pelvic (3D CRT) or intensity-modulated radiation …
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Exercise as medicine : reversing treatment toxicities in prostate cancer patients
… cancer after skin cancer in Australian males, is androgen deprivation therapy (ADT). However, ADT is associated with an array of adverse effects including reduced bone and lean mass, loss of muscle strength, negative change in lipid profile, and increased risk of cardiovascular disease (CVD) as …
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Exercise and nutrition induced weight loss for prostate cancer patients
… examining prostate cancer patients receiving androgen deprivation therapy (ADT) and how exercise and nutrition interventions can be used to induce fat loss, while preserving or improving lean mass. Study 1 (Chapter 4) is an examination of the efficacy of a weight loss program in altering body …
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
<p>Androgen receptor (AR) plays an important role in prostate cancer (PCa) development and has been the main therapeutic target in advanced PCa. AR expression is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR …
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The Role of Exercise on Masculinity, Body Image, and Quality of Life in Men with Prostate Cancer. A Mixed Methods Study.
… limited treatment groups (i.e., those receiving androgen deprivation therapy) and did not include men from across the exercise spectrum. Following a systematic review of the literature, we implemented a mixed methodology approach to gather both quantitative and qualitative information surrounding …
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Comparing Different Methods of Applying Propensity Score in Controlling Selection Bias for Studies of Prostate Cancer
… between patients with and without primary androgen deprivation therapy. The known confounding factor, cancer grade, was removed in the analyses to evaluate the selection bias for cancer severity. Results: Among four propensity methods, matching (greedy matching and caliper matching) …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… localised PCa is commonly treated with radiotherapy or surgery where recurrent tumours are treated with hormone therapy, such as androgen-deprivation therapy (ADT) and/or androgen receptor (AR) antagonists, e.g. Enzalutamide (ENZ). Castrate-resistant disease, where tumours become resistant to …
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A randomised controlled trial of a diet and physical activity intervention in prostate cancer patients and related studies.
The utilisation of Androgen Deprivation Therapy (ADT) in prostate cancer patients is associated with a number of adverse side effects including: changes in body composition; an increase in fat mass and a decrease in muscle mass, increased fatigue and a reduced Quality of Life (QoL). Existing …
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Translational perspectives on MSMB and CRISP3 expression and regulation in prostate cancer
… of both MSMB and CRISP3 was induced by androgen in vitro, and MSMB was decreased in patients receiving androgen deprivation therapy prior to radical prostatectomy. MSMB was virtually lost in advanced prostate cancer, in contrast to CRISP3 which was highly expressed. Inflammation has been …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… primary or acquired resistance to conventional androgen-deprivation therapy (ADT) and accumulated resistance mechanisms to evade androgen receptor (AR) suppression. Whereas the canonical androgen/AR signaling axis maintains prostate cell growth, differentiation and survival, in prostate cancer …
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Evaluating the role of a 99mTc-HYNIC-PSMA SPECT scan following a negative bone scan in men with prostate cancer: a single-centre, retrospective cohort study
… both scans negative included external beam radiotherapy (EBRT) and androgen deprivation therapy (ADT) (n = 47), and radical prostatectomy with or without lymph node (LN) dissection (n = 4). A limiting factor was that not every patient underwent conventional cross-sectional imaging of the pelvis …
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Nutritional factors and lifestyle in prostate cancer patients
… specifically for those who are treated with androgen deprivation therapy (ADT). To achieve these aims this thesis has documented the findings of the following studies investigating nutritional and life-style behaviours in prostate cancer patients. <br/>1) Using the cross-sectional …
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Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells
… men. Prostate cancer can be categorized as androgen dependent or androgen independent, indicative of the tumor’s ability to respond to testosterone stimulation. Currently available treatments include prostatectomy, radiation therapy, androgen deprivation therapy, immunotherapy, and …
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Prostate Specific Membrane Antigen (PSMA): Immunoassay Development and Characterization of Transcriptional Regulation
… malignant tumor and signal the development of androgen independent and metastatic tumor are needed. A biomarker designated prostate specific membrane antigen (PSMA) has the potential to fulfill this need. The objective of this study is to develop a clinically useful immunoassay for quantitation …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… er/detailedguide/prostate-cancer-key-statistics). Androgen deprivation therapy (ADT) is the standard treatment for early stage prostate cancer. But most patients relapse with aggressive variants of prostate cancer, with survival time between 1-3 years. In order to develop cure for such aggressive …
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Phage Display Library Screening For Psa-/Lo Prostate Cancer Cell-Binding Peptides
… cells responsible for driving PCa and mediating therapy resistance. My master thesis research employs a phage display library screening technology aiming to identify peptides that preferentially home in to undifferentiated PCa cells, which our lab has previously demonstrated to be intrinsically …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… American men. Men who fail standard-of-care androgen deprivation therapy (ADT) and progress to metastatic castration resistant prostate cancer (mCRPC) are left with few therapeutic options. Current second line therapies only provide a small survival benefit and there is a critical unmet need …
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