Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"androgen receptor signalling"”.
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… disease which affects men worldwide. The Androgen Receptor (AR) is responsible for driving disease progression, therefore therapies often target this signalling axis. Eventually, these treatments fail and the cancer progresses to an aggressive, incurable stage known as castrate-resistant …
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic compounds that …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and antioestrogens), which are successful in many patients, but therapy resistance represents a major clinical issue. The Androgen Receptor …
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The molecular actions of medroxyprogesterone acetate on androgen receptor signalling and the promotion of breast cancer.
… that MPA possesses antagonistic actions on androgen receptor (AR)-signalling and thereby can disrupt the protective effect of androgens in the breast, thus leading to an increased risk of breast cancer. Androgens have been associated with a growth restrictive role in breast tissue in both …
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CRISPR/Cas9 screenings and in silico investigations nominate low-frequency alterations in DNA repair genes as biomarkers for castration-resistant prostate cancers.
… DRG defects with patient outcome and response to androgen receptor-signalling inhibitors (ARSI) were performed. Multiple genes were validated as predictive biomarkers of PARPi or carboplatin response, while 14 DRG variants linked with worse prognosis or response to therapy were nominated by the in …
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Targeting anti-androgen resistance in prostate cancer using preclinical models with physiological nutrient levels
Prostate cancer is driven by upregulated androgen receptor signalling that regulates cellular growth and metabolism. While anti-androgen therapies such as Enzalutamide can be effective against prostate cancer, 60% of patients will develop Enzalutamide resistance which is currently incurable. Since …
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The role of microRNA-194 in prostate cancer progression
… While prostate cancer is primarily driven by the androgen receptor signalling, a number of other factors play important roles in its growth and progression. In particular, small non-coding RNA molecules called microRNAs (miRNAs) are known to be key regulators of progression in prostate cancer. Our …