Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 140 for “"androgen receptor"”.
-
Androgen Receptor and Prostate Cancer Cell Heterogeneity
<p>Androgen receptor (AR) plays an important role in prostate cancer (PCa) development and has been the main therapeutic target in advanced PCa. AR expression is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR …
-
Associations Between Testosterone, Androgen Receptor Polymorphism, And Mood
… affect in men. Genetic variability in the androgen receptor (polyglutamine [CAG] repeat length) may be important for this relationship. However, the relationship between testosterone, androgen receptor CAG repeat length, and depressive affect remains inconclusive. The current thesis …
-
Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… on the expression of three markers estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor (HER2). Breast cancers that express these targets are classified as hormone receptor (HR) positive breast cancer and the tumors that lack the expression of these …
-
Genetic, environmental and life-style effects on androgen receptor function
Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. Prostate specific antigen (PSA) is a downstream target …
-
Synthesis and androgen receptor binding of novel derivatives of dihydrotestosterone
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… disease which affects men worldwide. The Androgen Receptor (AR) is responsible for driving disease progression, therefore therapies often target this signalling axis. Eventually, these treatments fail and the cancer progresses to an aggressive, incurable stage known as castrate-resistant …
-
Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. <br/><br/>The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), …
-
The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and antioestrogens), which are successful in many patients, but therapy resistance represents a major clinical issue. The Androgen Receptor …
-
Proteolysis targeting chimeras for the directed ubiquitination of the androgen receptor
… a cellular environment. This work focuses on the androgen receptor (AR) protein, a key nuclear receptor for healthy prostate development. Hence, AR inhibition and degradation are well-established strategies for treatment of prostate cancer. First, in this work stapled peptide PROTACs recruiting E3 …
-
The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… In a previous study, we identified a novel androgen receptor (AR)-interacting protein (p44/WDR77) and found that it plays a critical role in the control of proliferation and differentiation of prostate epithelial cells. In the present study, we found that deletion of the p44 gene in the …
-
Computational Molecular Docking Models and Design of Diarylpentanoids for the Androgen Receptor
<p>The androgen receptor (AR) is a member of the nuclear receptor protein family that, upon binding to its natural ligand dihydrotestosterone (DHT) in the cytoplasm, translocates to the nucleus and exerts nuclear transcription factor activity to drive gene expression related to normal prostate …
-
Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
Androgen receptor (AR) signaling is crucial to the development, growth, and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies, including benign and malignant forms of neoplasia. Prostate cancer is the second most prevalent cancer and the sixth leading …
-
Designed bifunctional proteins for induced degradation of androgen receptor in prostate cancer
The transcription factor androgen receptor (AR) is a key driver of prostate cancer, the most frequent cancer among European men. Most available AR inhibitors compete with endogenous ligands by blocking the ligand-binding pocket, which is an effective treatment in many patients. However, escape …
-
Physiological and pathological role of serine 96 phosphorylation in the regulation of androgen receptor
… encoding a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. SBMA belongs to the family of polyQ diseases, which includes eight other neurological diseases caused by the same mutation in unrelated genes. PolyQ diseases share common features, such as that polyQ proteins are …
-
Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo
The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 …
-
Mechanistic investigation of an anticancer agent that damages DNA and interacts with the androgen receptor
The 11[beta] molecule comprises a ligand for the androgen receptor (AR), which is crucial to progression and survival of many prostate cancers, tethered to a DNA-damaging aniline mustard. The compound was designed to exhibit selective toxicity toward prostate cancer cells by forming sites of …
-
Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
… (cancer) of the liver. HCC has been known as androgen-dependent tumor with incidence of five times higher and worse prognosis in male than female. Steroid hormones and their receptors play a major role in the development of many types of human and animal cancers. It has been known that …
-
The molecular actions of medroxyprogesterone acetate on androgen receptor signalling and the promotion of breast cancer.
… that MPA possesses antagonistic actions on androgen receptor (AR)-signalling and thereby can disrupt the protective effect of androgens in the breast, thus leading to an increased risk of breast cancer. Androgens have been associated with a growth restrictive role in breast tissue in both …
-
The androgen receptor independent mechanism of toxicity of the novel anti-tumor agent 11[beta]-dichloro
… mustard moiety to a steroid ligand for the androgen receptor (AR). In vitro and in vivo (cell cultures, mouse xenografts) studies highlighted the potent antitumor properties of the molecule, which can prevent growth of AR positive tumor xenografts in mice. However, 11 p-dichloro also proved …
Page 1 of 7