Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 467 for “"and therapy"”.
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Imaging and therapy in multiple sclerosis
… extra-lesional abnormalities are recognised and appear most marked at the outer (subpial) brain surfaces at post-mortem. Magnetisation transfer ratio (MTR) is a non-conventional MRI sequence that correlates with myelin density and axonal count, and has recently uncovered reductions in the …
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Pathogenesis and Therapy of Mitochondrial Diseases
… which is composed by one catalytic subunit POLγA and two accessory subunits POLγB. Mutations in the nuclear-encoded POLG gene, coding for POLγA, are a common cause of human disease leading to a spectrum of disorders characterised by mtDNA instability, thus compromising mitochondrial function. …
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Trans-skull Ultrasound for Imaging and Therapy
… emerged as a novel modality for the treatment and imaging of brain diseases. When enhanced by circulating microbubble agents, which scatter sound and vibrate in response to the incident ultrasound, it can enable a range of new therapeutic interventions and open new possibilities for imaging. …
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Multifunctional Nanoparticles for Cancer Imaging and Therapy
… offered new possibilities in cancer detection andtreatment. Through the use of multifunctional nanoparticles, researchers aim to address current limitations of cancer therapy by expediting the detection of the disease and improving the therapeutic efficacy of drugs while confining their effect …
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Engineered Nanomaterials for Targeted Imaging and Therapy
… can help direct the best treatment strategy and improve patients' survival. The unique and tunable properties of nanoparticles facilitate the development of diagnostic imaging tools for earlier diagnosis and disease staging, and they can provide fundamental information on the pathological …
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Investigating the pathogenesis and therapy of Friedreich Ataxia
… FRDA is associated with cardiomyopathy and an increased risk of diabetes mellitus. Currently there is no effective therapy for FRDA and this is perhaps due to the lack of an effective system to test potential drugs. Therefore, the main aim of this thesis is to develop a novel cell …
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Investigating immune surveillance, tolerance, and therapy in cancer
Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems largely relied on chemically-induced and spontaneous tumors in immunodeficient …
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Multifunctional Hybrid Theranostic Nanoplatforms for Cancer Imaging and Therapy
Cancer remains a leading cause of morbidity and mortality worldwide, with millions of new cases diagnosed each year and a significant number of deaths attributed to the disease. Traditional cancer treatments like surgery, chemotherapy, and radiation therapy often face limitations, including …
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Dynamics of HIV-1 Infection and Therapy In Vivo
… a disease responsible for extensive morbidity and mortality worldwide. Despite more than thirty years of research since the discovery of HIV-1, no cure or vaccine yet exists. HIV-1 infection, while treatable with suppressive antiretroviral therapy drugs (ART), establishes lifelong persistence …
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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
… of non-invasively capturing detailed, real time and spatially resolved biochemical information in vivo and thus delineating disease so that non-invasive curative resection or treatment of the affected area can take place. Though visible and near infrared (NIR) light undergo a wide range of …
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Enhancers and super-enhancers in human disease and therapy
… of cell types, each with specialized properties and functions that support the organism as a whole. Despite this variability, with few exceptions, these cells contain the same genetic information. The incredible diversity in cellular function arises from differences in gene expression between …
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Robust network calibration and therapy design in systems biology
… represent the modeler's systems-level understanding of network functionalities. Computational methods that enhance the usefulness of mathematical models are thus being increasingly sought after, as they face a variety of difficulties that originate from limitations in model accuracy and …
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Shape dependent iron oxide nanoparticles for simultaneous imaging and therapy
… of iron oxide nanoparticles of varying sizes and shapes. Specifically, large (>4 nm) spherical particles, ultrasmall (<4 nm) nanoparticles, and ultrathin (2x20 nm) nanowires were synthesized by thermal decomposition of an iron oleate precursor. To render the nanoparticles biologically …
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Early Intervention, Research and Therapy Center for Children with Autism
This book documents a design study and creative project undertaken toward the fulfillment of a Masters of Fine Arts Degree in Interior Environments at Virginia Commonwealth University in Richmond, Virginia. This book documents a year long accumulation of study and research done toward the …
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Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy
… proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of …
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Fairytales and Therapy: Using Fairytales in Assessing for Child Abuse
… of reported child abuse are rising every year and many of the social workers and therapists evaluating these victims are overloaded. This pilot study evaluates whether fairytales may be used in assessing for child abuse. A correlational study was conducted using children from both abused and …
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Development of tumour imaging and therapy strategies utilising unengineered bacteria
… of systemically administered bacteria to target and replicate to high numbers within solid tumours is well established. Tumour localising bacteria can be exploited as biological vehicles for the delivery of nucleic acid, protein or therapeutic payloads to tumour sites and present researchers with …
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