Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"and Rho"”.
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High-Energy Photoproduction of the Rho and Rho' Vector Mesons
Made available in DSpace on 2015-05-13T15:22:08Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7803944.PDF: 4571254 bytes, checksum: 870aeca9f3117126034c37a4c1c6eea6 (MD5) Previous issue date: 1977
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Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, lovastatin also contradictorily relieves or exacerbates memory loss in Alzheimer's patients (Wagstaff et al., 2003; Sparks et al., 2008). We postulate that some of …
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Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
… receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns around, which ultimately leads to the repulsive guidance of the axon. Structural studies by our laboratory and …
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… often been shown to correlate with the migration and accumulation of T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration and are often involved in cancer progression. Most of these proteins are post-translationally isoprenylated to facilitate …
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An Optical Flow Based Methodology for Visualizing Dynamic Sucellular [sic] Organiztion [sic] Demonstrated Through Profilin and Rho GTPase Microdomains
… Statistical time series analysis can greatly expand our understanding of subcellular interactions in minimally perturbed systems. This was previously achieved for the leading edge of migrating cells in select cases. Importantly no strategy existed to simultaneously analyze every subcellular …
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Using Nuclear data and Monte-Carlo techniques to study areal density and mix in D² inertial confinement fusion implosions
… models for determining hot-fuel areal density ([rho]Rhot) in compressed, D2-filled capsules, and to assess the impact of mix and other factors on the determination of pRhot. The results of the Monte-Carlo calculations were compared to predictions of commonly used models that use ratios of either …
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Microwave synthesis and occlusion reactions of zeolites
… synthesis of zeolites A (LTA), X (FAU), Y, (FAU) and rho (RHO) in a microwave oven. Results have demonstrated that when zeolitic gels are heated in a microwave oven they yield zeolite crystals far quicker than when heated in a conventional oven. This is in part a consequence of the rapid heating …
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Passive Electrical Properties of Horizontal Cells in the Retina of the Turtle, Pseudemys Scripta Elegans
… to 20 ms pulses of current in luminosity-type and chromaticity-type horizontal cells. The time course of the relaxation was described by the sum of two exponentially decaying processes. The passive responses were analyzed in terms of a finite cable model; values for equivalent electrotonic …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… Microvascular inflammation, including leukocyte and platelet recruitment as well as epithelial barrier dysfunction, are considered to constitute key components in the pathophysiology of radiation-induced enteropathy. The aim of this thesis was to investigate the basic mechanisms behind …
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Reconstruction of B- --> D*° e- nu Decays and Determination of |Vcb|
… the channels D*° --> D° pi°, D° --> K- pi+ and pi° --> gamma gamma. The neutrino is not reconstructed. Since the rest frame of the B meson is unknown, the boost w of the D*° meson in the B meson rest frame is estimated by w'. The w' spectrum of the data is described in terms of the …
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Modelling the endothelial cell response to fluid flow
… signal is transformed into an organised and directed response is poorly understood. The most studied and crucial aspects to this response are; actin filament alignment, mechano-transduction, signal transduction, Rho GTPase localised activation and lamellipodium formation. The goal of this …
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Molecular Control of the Migratory Phase During Cutaneous Wound Healing
… subcellular analysis, molecular manipulation and various imaging techniques of in vivo and in vitro wound models, this project has discovered that the autophagy pathway is activated in response to injury and also that the resultant autophagosomes form in a polarised manner towards the trailing …
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Dual Mechanisms of Cognitive Control: A Hierarchical Bayesian Approach to Test-Retest Reliability
… working memory, reasoning, problem solving, and decision making. Currently, no existing theory of cognitive control unifies experimental and individual differences approaches. Some even argue that cognitive control as a psychometric construct does not exist at all. These disparities may exist …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… which is partly related to an incomplete understanding of the basic pathophysiology behind the disease. It is widely held that premature intra-cellular trypsinogen activation and leukocyte recruitment play key roles in the pathophysiology of the AP. However, the signaling and adhesive mechanisms …
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Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network
… cellular events are altered by KAI1/CD82 and how KAI1/CD82 regulates these events. We found that KAI1/CD82-overexpressing cancer cells exhibit various morphologies but typically display elongated cellular extensions and a lack of lamellipodia. Live imaging demonstrated that the formation …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. We found that nerve-induced contractions are mainly dependent on muscarinic receptor activation in the newborn whereas …
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Integration of signalling in smooth muscle caveolae
Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth …
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A Synthetic Lethal shRNA Screen and Genetic Proof of Concept Identifies RAC1 as a Novel Target to Disrupt Plexiform Neurofibroma Formation
… therapeutic targets to disrupt PN formation and progression. An shRNA library screen of human kinases and Rho-GTPases was performed in NF1-/- and paired NF1 competent immortalized Schwann cell lines. Following sequencing, candidates were identified. We previously developed a novel mouse model …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… led to an increase in PIP-5-kinase activity and to elevated PIP2 levels in intact cells. As both PLD and PIP-5-kinase are stimulated by the GTPases Arf1 and RhoA, we investigated in the following, if PLD is involved in the regulation of PIP2 synthesis by these GTPases. Both PLD1- and …
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