Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"and Proteasome"”.
-
Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… decades, global implementation of vector control and artemisinin combination therapies have resulted in significant reductions in the global burden of malaria. Of current concern is the spread of multi-drug resistant parasites that have severely limited the efficacy of antimalarials, including …
-
Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… role of some regulators of the ubiquitination and proteasome systems in cell death and innate immune signalling pathways in macrophages. Initial studies focused on a form of regulated cell death termed necroptosis, a type of cell death mediated by the receptor-interacting protein kinases (RIP). …
-
New Roles for the Integrated Stress Response in Cancer and Proteostasis
… conserved pathway that senses diverse stresses and responds by limiting total protein synthesis and redirecting translation to stress response transcripts. The ISR has the potential to modify a broad range of processes in cancer, but the major cancer-relevant functions of the pathway have …
-
Loperamide enhances bortezomib-mediated cell death in colon cancer cells
I. INTRODUCTION 1 II. MATERIALS AND METHODS 8 A. Chemicals and antibodies 8 B. Cell culture of various cancer cell lines and normal cells 8 C. Measurement of cell viability 9 D. Western blotting 9 E. Immunocytochemistry 10 F. Establishment of the stable cell lines in the fluorescence specifically …
-
Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… at high levels through eutrophication, hypoxia and loss of biodiversity, it is considered to be physiologically inert to the individual aquatic organism. To test the physiological effects of nitrate on aquatic life, we exposed gill tissue of the Pacific oyster, Crassostrea gigas, to nitrate and …
-
Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… malignant neoplasm derived from dendritic cells and histiocytes, with no available effective treatment options. Akt signaling and proteasome dysfunction have been implicated in the pathogenesis of the disease, both in humans and dogs. Our work aims to investigate the importance of the Akt …
-
Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… protein synthesis, protein degradation, and epigenetic regulation of gene expression, throughout a circuit of brain regions. One mechanism highly studied for its involvement in protein degradation during fear memory is the ubiquitin-proteasome system (UPS), which utilizes the small …
-
The mechanisms regulating the transcription factor ATF5 and its function in the integrated stress response
… is an important mechanism regulating global and gene-specific translation during different environmental stresses. Repressed global translation by eIF2 phosphorylation allows for cells to conserve resources and elicit a program of gene expression to alleviate stress-induced injury. Central to …
-
Control of DAPK-1 degradation
… including apoptosis, autophagy, cell survival and motility. The cytokine TNF-α has been reported to induce the degradation of DAPK-1. Here I identified the protease cathepsin B as a novel binding partner of DAPK-1 that protects DAPK-1 from TNF-α induced degradation. Using deletion mutants of …
-
Topographical Differences in Stress Vulnerability in Experimental Parkinson's Disease
… inclusions before the neocortex in the frontal and parietal lobes. In the present study we tested the hypothesis that the staged appearance of proteotoxicity in allocortex followed by neocortex is the result of intrinsic vulnerability differences. We microdissected the neocortex and multiple …
-
Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
… degradation. This work explores the design and characterisation of bifunctional protein constructs (Polyproxins) with two grafted binding regions to recruit E3 ubiquitin ligases to the target AurA. By simultaneously binding these two proteins there should be transfer of ubiquitin to AurA and …
-
A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
<p>The specific and timely degradation of proteins is achieved by the Ubiquitin-Proteasome System (UPS), which governs a variety of cellular processes such as apoptosis, cell cycle progression, protein quality control, and metabolism. Using this system, cells maintain homeostasis by quickly and …
-
Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
<p>AMPK activation and Ubiquitin Proteasome System (UPS) inhibition have gained great attention as therapeutic strategies for the treatment of certain types of cancers. While AMPK serves as a master regulator of cellular metabolism, UPS regulates protein homeostasis. Although the crosstalk between …
-
Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
… brain disorder resulting in memory loss and, eventually, an inability to perform simple tasks. Pathologically, AD brains accumulate insoluble protein aggregates known as neurofibrillary tangles (NFTs) and amyloid plaques. Definitive diagnosis of AD requires the presence of NFTs and …
-
Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease
… disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synphilin-1, interaction partner of α-Synuclein is a major component of inclusion bodies, but it is unknown how synphiln-1 contributes to the cellular and biochemical mechanisms of PD, and its normal functions and …
-
The Role of the Ubiquitin-Proteasome Pathway During Xylem Differentiation in <I>Zinnia elegans</I> Mesophyll Cells and <I>Arabidopsis thaliana</I>
A biochemical characterization of ubiquitin (Ub)-proteasome pathway activity was conducted in <I>Zinnia</I> mesophyll cell cultures to examine potential differences between differentiating cells of tracheary element (TE) cultures and non-differentiating cells of control cultures. The pathway is …
-
Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… control center for controlling both food intake and energy expenditure in order to maintain the body's energy balance and dysregulation of molecular processes in this region have been implicated in the development and progression of obesity. Recently, several studies have shown altered DNA …
-
Effects of Lubabegron supplementation on carcass traits, muscle fiber type, proteome profile and meat quality attributes of finished feedlot steers
Two thousand one hundred and sixty (2,160) British and Continental crossbred steers were supplemented (1, 4, 3.2 or 5.0 g/ton (DM basis) Lubabegron and a control diet (Experior; EX, Elanco Animal Health) for the last 28, 56, or 84 d of the finishing period resulting in twelve treatment …
-
MenzelJohannes_MSc_July_2013
… is clear that genomic stability, stress response and nutrient signaling all play critical roles in lifespan determination, but the precise molecular mechanisms and their often subtle influence on cellular function remain largely unknown. The Anaphase Promoting Complex (APC) is an evolutionarily …
-
Integrated cellular, proteomic and metabolite analysis of argyrin B with rational design approaches for immunoproteasome-selective inhibitors
The ubiquitin-proteasome system plays a critical role in cellular protein degradation and homeostasis. Current proteasome inhibitors (PI) present great efficacy against haematologic cancers due to the high secretory load creating an increased dependency on proteostasis, yet resistance and adverse …
Page 1 of 2