Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"anchorage-independent survival"”.
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Investigating lipid metabolism and gene expression in High Grade Serous Ovarian Cancer (HGSOC) disease progression and chemoresistance
… which requires metastatic cells to overcome anchorage dependence and avoid cell death via anoikis. Understanding the molecular drivers that underpin this stage of metastasis can highlight key effectors that could be targeted to prevent and reduce metastasis and recurrent disease after initial …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… HC11 cells expressing Brk exhibited increased anchorage-independent survival when cultured on PolyHEMA coated dishes. Samples from breast tumor biopsies were subjected to IHC analysis for co-expression of Brk, phospho-STAT5, and phospho-p38 MAPK. Ductal and lobular carcinomas expressing Brk …
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Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… similar to HNSCC and its mRNA signature predicts survival in non-HPV-related HNSCC. cuSCC is also similar to lung SCC as well as basal subtype of breast cancer. Our cross species analysis has identified key genomic drivers of cuSCC development as potential chemoprevention targets and suggests that …
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MUC13 Enhances Colorectal Cancer Metastasis
… crucial for CRC management. The overall 5-year survival of CRC jumps noticeably from 66% to 91% if it can be diagnosed and treated at early stages but drops down to 14% when the disease has metastasized. Metastasis is the cause of 90% of all cancer related deaths, which necessitates the need to …