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Showing 1 to 6 of 6 for “"anaplerosis"”.
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The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer
… atoms to be replenished by a process called anaplerosis. The work in this thesis shows that impinging on TCA cycle anaplerosis, either by impairing the breakdown of nutrients (glycolysis/glutaminolysis inhibition), or by restricting the import of blood-borne nutrients (angiogenesis …
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Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… to insulin secretion. We have found that anaplerosis via pyruvate carboxylase is essential for both phases of glucose-stimulated insulin secretion, presumably via generation of an increased ATP/ADP ratio. Further, we discovered that expression of PDK1 is upregulated in INS-1 832/13 cells …
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The Mechanism of Palmitate Decreased Glucose Transpoter 4 Expression in C2 Myotubes
… 지방산에 의한 synthesis 관련 약제의 영향 27 3. 고농도 지방산에 의한 anaplerosis 관련 약제의 영향 28 4. 고농도 지방산에 의한 stress kinase 관련 약제의 영향 28 5. 고농도 지방산에 의한 Ca2+ 관련 약제의 영향 29 6. 고농도 지방산에 의한 PI3-kinase signaling 관련 약제의 영향 29 C. 고농도 지방산에 의한 pyruvate 양적 변화 및 pyruvate와 palmitate 산화 변화 37 1. 고농도 지방산에 의한 pyruvate 양적 감소 37 2. 고농도 …
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PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
… malate-aspartate shuttling, amino acid anaplerosis, nitrogen recycling, and membrane/cofactor biosynthesis. In vitro, PERM1 silencing in C2C12 myotubes induced a compensatory shift toward glycolysis. AAV-PERM1 preserved systolic function and remodeled metabolomes modestly in the heart …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
Type 2 diabetes is considered to be in most cases a polygenic disease with a strong involvement of environmental factors, such as diet and exercise. Chronic exposure of high glucose and free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the …
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Modulation of host metabolism by the human gastric pathogen Helicobacter pylori
Cellular homeostasis is important for retaining cellular viability and functions, and often manipulated by bacterial pathogens as an effective target for remodeling the host environment for colonization. Helicobacter pylori, a human gastric pathogen that impacts more than a half the human …