Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"anaphylatoxin"”.
-
Herstellung und Charakterisierung monoklonaler Antikörper gegen die Anaphylatoxin-Rezeptoren
Anaphylatoxine sind potente Entzündungsmediatoren, die ihre biologische Wirkung durch eine hochaffine Bindung an spezifische, zelluläre Rezeptoren entfalten. Aufgrund der widersprüchlichen Angaben in der Literatur über die Expression der Anaphylatoxin-Rezeptoren sollten in der vorliegenden Arbeit …
-
Sphingosine-1-phosphate in mast cell-mediated allergic responses
… CD88, the receptor for C5a, and are activated by anaphylatoxin C5a and the secretagogue compound 48/80. S1P induced release of IL-6, a cytokine known to promote development of functionally mature MCTC, from cord blood cultures containing adherent macrophages, and from highly purified macrophages, …
-
Novel Endogenous Antimicrobial Peptides
… heparin-binding capacity were discovered for the anaphylatoxin C3a, generated during activation of the complement system, and the inactive derivative of C3a (C3adesArg), as well as shorter synthetic peptides from the molecule. Novel antimicrobial activity was also shown for the heparin binding and …
-
Plasmatische und zelluläre, nicht invasive Biomarker für die Diagnostik kardialer Abstoßungsreaktionen
… shown that platelets can be activated by the anaphylatoxin C3a. These points show the essential role of platelets in the context of immune reactions, since they provide indications for a local increase in the C3 concentration due to platelet activation. Furthermore, a hitherto undescribed …
-
Development and In-Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma
… its shortcomings including but not limited to anaphylatoxin production, platelet activation, immunogenicity, express a need for a better candidate for the same. This article explores the viability of poly(2-ethyl-2-oxazoline) conjugate for the development of long circulating liposomes for the …
-
The role of staphylococcal superantigen-like protein 7 (SSL7) in immune evasion
… activation as well as the generation of the anaphylatoxin C5a. Additionally, SSL7 efficiently blocked the formation of C5b- 9 on the surface of Gram-positive bacteria. External SSL7 or SSL7 expressed by the Gram-positive, avirulent Lactococcus lactis enhanced survival of the bacteria in a …
-
STRUCTURAL, FUNCTIONAL AND EVOLUTIONARY STUDIES OF ANTIMICROBIAL PEPTIDES
… thesis show that antimicrobial domains of the anaphylatoxin C3a are structurally and evolutionary conserved. Moreover antimicrobial activity is not governed by a single factor, but instead by a combination of net charge, amphipathicity and helicity. By utilizing a low number of amino acid …
-
Measurement and mechanisms of complement-induced neutrophil dysfunction
Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in critically ill patients is driven by inflammation-associated organ damage and a profound vulnerability to nosocomial infection. Both factors are …