Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"anaphase-promoting complex (APC/C)"”.
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Enhanced protein degradation by branched ubiquitin chains
… roles of branched structures are unknown. The anaphase-promoting complex (APC/C) catalyzes degradation of key regulators during the cell cycle causing proper transition through the cell cycle. Here, I report that the APC/C efficiently synthesizes substrate-attached branched conjugates and …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… revealed that TRAF2 plays a primary role in promoting caspase-2 dimerization and downstream apoptosis in response to DNA damage. Identification of a TRAF Interacting Motif (TIM) on caspase-2 indicates that TRAF2 directly acts on caspase-2 to induce its activation. TRAF2 is known to act as an …
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Molecular Mechanisms Involved in Chromosome Segregation
… and assembly of the human CCAN-CENP- ANuc complex, showing that CCAN tightly grips the linker DNA of the CENPANuc. CENP-C emerges as the main recognition protein of the inner kinetochore. CCAN topologically entraps the linker DNA, explaining how it can withstand both pushing and pulling …