Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"anaphase bridge"”.
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Characterization of the Role of Mcm10 in DNA Replication in Drosophila melanogaster
… such as condensation defects, aneuploidy, anaphase bridge defects, separated sister chromatids and chromosome breaks, were observed in varying frequencies suggesting that Mcm10 is involved in maintaining genomic stability. Additionally, the Mcm10 mutant strains showed defects in …
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Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
… knockdown there is an observed increase in anaphase bridge fromation, indicitive of elevated genetic instability. Examination of genes associated with good prognosis revealed genes involved in growth cone formation. Combination of the expressoin of growth cone associated genes with the …
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Post-Replicative Resolution of Under-Replication
… licensing factors. The number of ultrafine anaphase bridges and 53BP1 nuclear bodies are in remarkable concordance with the theoretical predictions for the number of double fork stalls, indicating that cells are able to tolerate under-replication through such post-replicative cellular …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural …