Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"anandamide"”.
-
EFFECTS OF ENHANCING ANANDAMIDE LEVELS ON HIPPOCAMPAL NEUROPHYSIOLOGY AND SHORT-TERM MEMORY PROCESSING IN RATS
… of the hippocampus. The acute effects of R-Methanandamide; VMD11 and URB597 were measured on firing rates, bursting characteristics and synchrony of hippocampal cells and performance of the DNMS task. R-methanandamide and URB597 but not VDM11 showed a consistent decrease in firing rates, burst …
-
Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… (ii) investigate the functional response of anandamide (AEA) in the murine carotid artery, (iii) investigate the effects of cannabinoids on SMC proliferation, and (iv) to establish the effects of cannabinoids on SMC migration. The organ culture model developed in this study demonstrated the …
-
A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… was to evaluate whether elevating endogenous anandamide levels using mice lacking fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide metabolism, would ameliorate THC dependence. Mice were treated subchronically with a low or high THC dosing regimen and challenged with the …
-
Bioactive Lipids in Nociception
… in the level of 2-AG, whereas the levels of anandamide and 2-oleoylglycerol were unaffected. Extensive metabolism of d8-2-AG and d5-1-AG, in contrast to d8-anandamide, was demonstrated in homogenates of rat mesenteric arteries. The monoacylglycerol lipase inhibitor MAFP prevented the …
-
Microvascular inflammatory response in the skin
… skin using laser Doppler perfusion imaging. Anandamide, capsaicin, olvanil and arvanil all caused concentration-dependent increases in skin perfusion after skin prick test. Co-application of capsazepine inhibited the response. The results indicate a role for anandamide as a pararcrine …
-
Discriminative stimulus properties of 3-substituent rimonabant analogs
… O-6629, whereas the cannabinoid agonists THC and anandamide did not. O-6629’s discriminative stimulus failed to generalize to rimonabant, cocaine or morphine, whereas WIN 55,212-2 and nicotine evoked partial substitution. These results suggest that these analogs might exert their pharmacological …
-
The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… this is accompanied by an increase in levels of anandamide. Feeding aged animals EPA or DPA further increased the levels of EPA-EA but prevented any change in the level of anandamide. Niacin is used to treat hypercholesterolaemia although it is associated with an unpleasant PGD2 mediated skin …
-
Possibile ruolo del sistema endocannabinoide nel disturbo d’alimentazione incontrollata (binge eating disorder): studi comportamentali, farmacologici e biochimici
… experimental evidence. Elevated plasma levels of anandamide were found in women affected by AN and BED. Moreover, anandamide levels were inversely correlated with plasma leptin concentrations. On the basis of these evidence, the aim of this thesis was to study whether and which elements of the …
-
Modulation of synaptic transmission by TRP channels
… transmission at the first sensory synapse. Anandamide (AEA) is an agonist of CB1/CB2 and TRPV1 receptors; it is less potent at TRPV1 receptors than capsaicin. AEA increased sEPSC frequency in 70% of neurons, whereas the remainder of neurons showed a decrease in sEPSC frequency. Unlike …
-
Biosynthesis of Long-chain Fatty Acid Amides
… N-acylethanolamine, N-arachidonoylethanolamine (anandamide), as the endogenous ligand for the cannabinoid receptors in the mammalian brain. Since this discovery, the details of N-acylethanolamine metabolism have been elucidated. However, a lesser extent of progress has been made in the last …
-
Targeting the Endocannabinoid System to Reduce Inflammatory Pain
<p>The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol …
-
Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
… of the endocannabinoid/ endovanilloid, anandamide (AEA). Regulation of synaptic AEA concentrations is critical to homeostatic control of neurotransmitter release since AEA can act both at CB1Rs, to depress neurotransmission, and TRPV1 channels, to enhance glutamate release. I demonstrate …
-
Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… dampened motor map expression and that both anandamide (AEA) and 2-arachidonoylglycerol (2-AG) contributed to this effect. Activation of CB1R signaling did not affect skilled reaching task performance. However, a lack of cannabinoid signaling resulted in impairment on performing the reaching …
-
Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
… levels of the endogenous cannabinoid agonist anandamide (URB597 and PF3845), and a selective CB2R agonist, GW405833. THC was also tested in assays of LPS-stimulated mechanical allodynia and LPS-depressed ICSS. In general, mixed CB1R/CB2R agonists were ineffective or exacerbated pain-depressed …
-
Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… (CB2 selective agonist), and the endocannabinoid anandamide (AEA) in periodontal disease. Our primary investigation led us to evaluate the most potent stimuli for the study, from which IL-1β emerged as the most robust inducer of cytokine and chemokine responses. The study was further expanded to …
-
Physical fitness and exercise as modulators of the endocannabinoid system in adults with mild-to-moderate depression the sonrie study
… and most well studied endogenous ligands are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These components, along with associated analogues interact with CB1 and CB2 receptors. CB1 receptors are abundant in the central nervous system and implicated in cognitive, emotional, and motor …
-
Endocannabinoid regulation of gastric vagal afferent signalling
… ghrelin cells. Further, the endocannabinoid anandamide (AEA; ligand for CB1) is expressed in the stomach. However, it is not known if ECs, ghrelin, and TRPV1 interact to regulate GVA sensitivity. Aims: To determine in lean and diet induced obese mice: 1. The co-expression of CB1, TRPV1, and …
-
Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… cardiac remodelling, and significantly elevated anandamide (AEA) and 2-AG levels in brain, heart and aortic tissues. Supplementation of the atherogenic diet with the EPA, while having a negligible impact on endothelial dysfunction or cardiac remodelling, improved the hypercholesterolaemic profile …
-
Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans
… endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide (AEA) and congeners in normal-weight PROP super-tasters and non-tasters, also we assessed the cognitive eating behavior disorder by the Three-Factor Eating Questionnaire. The results showed that: 1) Basal levels of II-2 and Ps-1 proteins, …
-
Distribution and function of TRP ion channels in primary sensory neurons
… and mesenteric artery. The CB1 receptor agonists anandamide and HU210 also fail to inhibit TRPV1-mediated calcitonin gene-related peptide (CGRP) release from primary sensory neurons in rat hindpaw skin and mesenteric artery. Therefore, this study do not support the general view that the analgesic …
Page 1 of 2