Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"analgesic tolerance"”.
-
Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… complex in nociceptive neurones for morphine analgesic tolerance; c-Src (a tyrosine kinase), thought to couple to MOP receptors through BAR2 has<br/>also been implicated.<br/><br/>To investigate opioid receptor signalling in response to morphine we used a variety of different techniques that …
-
Pharmacological Characterization of Novel Opioid Receptor Ligands Aimed at Reducing the Development of Tolerance
… associated with analgesia. Traditional opioid analgesics exert their effects through mu receptors located in the CNS. Recent studies suggest that the development of opioid analgesics displaying dual properties of mu agonism and delta antagonism could be of benefit by retaining potent analgesic …
-
The Interaction of Pain and Morphine on Analgesia, Locomotion, and Cognitive Functioning
… can be complicated by side effects like tolerance and mental clouding which, themselves, can be disabling. The present study examined the independent and combined effects of inflammatory pain and opioid medication on spatial memory for a well learned task in Sprague-Dawley rats. The …
-
The Impact Of The Inhibitory Neuromodulator Agmatine On Microglia Function In The Contexts Of Pain And Addiction
… However, long-term use of opioids can lead to analgesic tolerance, dependence, uncontrolled opioid use, and overdose. The impact of this crisis, and the related opioid epidemic, is especially felt in the exponential increase in opioid-related overdose deaths over the last decade. Moreover, …
-
Increased Microglial Reactivity Alters Morphine Analgesia
Opioids are a potent class of analgesics in the management of both moderate to severe acute pain and chronic pain. Although neuronal response to opioids is well described, we are lacking a complete characterization of the diverse interplay of neurons with other cells types in response to opioids. …
-
Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… effects of opioids including analgesia, tolerance, hyperalgesia, locomotor function and reinforcement.<br/><br/>We generated FC in post-natal day (PD) 2-9 mice and investigated their nociception and morphine analgesia, tolerance, hyperalgesia, hyperlocomotion and reinforcement at …