Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"amyloidogenesis"”.
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Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis
… study of aromatic $\pi$-stacking interactions in amyloidogenesis. The basic thermodynamic parameters of FF assembly, the kinetics of that process, and the similarities with, and differences from, the process of fibrillogenesis in polypeptides are explored in detail. The solubility of …
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Amyloidogenesis of a Type III-dependent Hpa1 and Structural analysis of a drug-pump repressor DNA complex
Abstract Part I Amyloidogenesis of Type III-dependent Hpa1 from Xanthomonas oryzae pv. oryzicola The first harpin, HrpN from Erwinia amylovora, the bacterium that causes fire blight of pear, apple and other rosaceous plants, was reported as an HR (hypersensitive response) elicitor in 1992. Similar …
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Identification and charaeterization of IAPP-derived inhibitors of cytotoxic self-assembly and amyloidogenesis of islet amyloid polypeptide (IAPP) and beta-amyloid peptide (A beta)
… cytotoxic protein/polypeptide self-assembly and amyloidogenesis are important targets of therapeutic intervention in protein aggregation diseases. The concept underlying the here presented studies was based on the hypothesis that bifunctional soluble IAPP mimics which combine bioactivity with the …
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Prediction of parallel in-register amyloidogenic beta-structures In highly beta-rich protein sequences by pairwise propensity analysis
… globular beta-helix proteins and prevent their amyloidogenesis; their presence in a sequence is a powerful negative predictor of amyloid potential. Together, these algorithms permit detection and structural analysis of protein amyloidogenicity from sequence data, enhancing the experimental …
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The role of phospholipase D1 in trafficking and processing of amyloid precursor protein
… of APP from endosomes, a primary station for amyloidogenesis, to the Golgi complex, while PLD1 overexpression produces the converse phenotype. Pld1 null mice harboring familial AD-linked (FAD) APP mutations exhibited decreased brain amyloid and an accumulation of APP COOH-terminal fragments. …
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Investigating the role of estrogen deprivation and diet-induced insulin resistance on markers of amyloid-β production and degradation in the brain
… tissues were then isolated and markers of amyloidogenesis, Aβ degradation, insulin signaling, glucose uptake, and synaptic function were examined. Independently, OVX led to increases in the amyloidogenic marker, sAPPβ. Furthermore, HFD combined with OVX, led to lower IDE protein content and …
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Investigating the physiological function of BACE1 and its role in metabolism
… AD post-mortem. The rate limiting step in amyloidogenesis is the activity of the aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Whilst the function of this enzyme has been well studied within the context of AD, very little is known about its physiological …
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Microfluidic device and interfacial transport: application to biomolecules and nanostructures
… of growth reveal new insights on the kinetics of amyloidogenesis as well as allows me to identify the minimum stable nucleus size. This is an important result owing to its implications in the understanding and early diagnosis and therapy of the Alzheimer’s disease
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Cellular Trafficking and Processing Pathways of the Alzheimer β/A4 Amyloid Precursor Protein
… amyloid domain, precluding the possibility of amyloidogenesis for that population of molecules. The routes of APP processing were examined in metabolically labeled PC12 cells treated with agents known to affect specific cellular functions. Treatment with either monensin or brefeldin A (BFA) …
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Characterization of Oxidized Tau Protein Aggregation and Inhibition of Tau Aggregation via MAP2
… modification that plays a role in the amyloidogenesis of Tau. However, conflicting reports left some uncertainty, stating that intramolecular oxidized Tau monomers were incapable of forming fibrils. Our lab decided to investigate this further because cellular oxidative stress has gained …
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Analysis of gamma secretase regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems
… by ?-secretase. Recent work suggests that amyloidogenesis is highly dependent on the levels of cholesterol within plasma membrane/early endosomes’ microdomains termed “rafts”. Indeed APP cleaving machinery, required for A? generation has been shown to reside in lipid rafts and the secretase …
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Post-translational processing of proteins implicated in the pathogenesis of Alzheimer's disease.
… sequence) in studies of APP processing and amyloidogenesis, since only APP was concentrated in compartments beyond the Golgi apparatus. Heat-shock and no feeding had no immunocytochemically detectable effects on APP or APLP2 distributions or 13-amyloid production in NT2 cells. Although a …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
… nucleation events, oligomeric conversion, and amyloidogenesis. Moreover, the application of chemical kinetics can provide fundamental information that further quantifies the inhibitory potential of therapeutics for a given amyloid system. This serves as an additional tool to be exploited in the …
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Wpływ przepływu mikrofluidycznego oraz nanocząstek metalicznych na właściwości amyloidogenne ludzkiej cystatyny C
Celem pracy było zbadanie wpływu nanocząsteczek tlenku miedzi(II) (CuO NPs) na strukturę, stabilność i agregację ludzkiej cystatyny C (HCC) oraz określenie, czy powstające agregaty wykazują aktywność biologiczną. Nanocząstki CuO otrzymano syntetycznie i potwierdzono ich jednorodność, stabilność …