Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"amyloid proteins"”.
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Biochemical and Structural Studies of Amyloid Proteins
Amyloidogenic neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are an important health issue. However, the underlying molecular mechanisms of the disease-related protein aggregates, that are present in humans, are only understood partially. I have used and …
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Graphene Microelectrode Arrays to Combine Electrophysiology with Fluorescence Imaging of Amyloid Proteins
… Both diseases are linked to the misfolding of proteins from their native conformational state into $\beta$-sheeted amyloid fibrils. In AD the implicated proteins are amyloid-$\beta$ and tau, and for PD the implicated protein is $\alpha$-synuclein (aSyn). The motivation for this work is to …
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SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT
… investigate the bovine acute phase protein Serum Amyloid A, focussing on its value as safety marker in farm animals. SAA can be considered as a natural anti-inflammatory and immunomodulatory agent and local expression of SAA, at the site of the initial acute phase reaction, could protect against …
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Dynamic Measurements with Scanning Probe Microscopy: Surface Studies Using Nanostructured Test Platforms of Metalloporphyrins, Nanoparticles and Amyloid Fibrils
… materials at the nanoscale. Samples of designed amyloid proteins were characterized ex situ using scanning probe microscopy. The progressive growth and fibrillization of amyloid â over extended time intervals was visualized with high resolution using AFM.
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Biophysical methods to study the ubiquitination of amyloidogenic proteins and proteasomal responses to protein aggregates
The accumulation of misfolded proteins is a universal mechanism in neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and prion disease. In mammalian cells, the majority of misfolded proteins are degraded by the ubiquitin-proteasome system (UPS), in which …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… diseases are reported to be associated with amyloidogenic peptides and proteins, for example, β amyloid (Αβ) in senile plaques of Alzheimer's disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the …
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Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP)
Aggregation of proteins into amyloid deposits is a common feature among dozens of diseases. Two such diseases that feature amyloid deposits are Alzheimer's disease (AD) and type 2 diabetes (T2D). AD toxicity has been associated with the aggregation and accumulation of the amyloid β-peptide (Aβ); Aβ …
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Investigating the Electrostatic Properties and Dynamics of Amyloidogenic Proteins with Polarizable Molecular Dynamics Simulations
Amyloidogenic diseases, such as Alzheimer's disease (AD) and Type II Diabetes (T2D), are characterized by the accumulation of amyloid aggregates. Despite having very different amino-acid sequences, the underlying amyloidogenic proteins form similar supramolecular fibril structures that are highly …