Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"amyloid plaque"”.
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Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… arthritis (CIA) on cognitive function, amyloid plaque formation, microglial activation, and cerebrovascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund’s …
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Genetic Reduction of Cholesterol Synthesis in the Mouse Brain Does Not Affect Amyloid Formation in an Alzheimer’s Disease Model, but Does Extend Lifespan
… content or synthesis affect the cleavage of amyloid precursor protein (APP) to amyloidogenic peptides characteristic of Alzheimer’s disease (AD). To determine whether a decrease in cholesterol synthesis would affect APP processing in vivo, we crossed cholesterol 24-hydroxylase knockout (KO) …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… region-specific deposition of extracellular amyloid plaques principally comprised of the amyloid-β: Aβ) peptide. Using mouse models of cerebral Aβ deposition, we examined molecular, cellular and systems-level mechanisms that regulate brain region-specific Aβ accumulation …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… the possible relationship between CB1 loss and amyloid plaque burdens as well as synaptic deficits. Furthermore, the effect of CB1 inverse agonists suppressing the non-amyloidogenic APP cleavage mediated by muscarinic agonist in SH-SY5Y neuroblastoma cell line suggest the loss of protection …
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
… Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or …
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Place cell physiology in a transgenic mouse model of Alzheimer's disease
… task and with hippocampal, but not neocortical, amyloid plaque burden. Additionally, pilot data show that physiological changes of the hippocampus in tg2576 mice seem to start as early as 3 months, when no pathological and behavioural deficits are present. However, these changes are not obvious …
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Supercharging: An Investigation into the Effects of External Amino Acid Residue Charge on the Solubility and Internal Electric Character of Bound Ligands in a Heme-Binding de novo-Designed Protein
… positive charge increased the likelihood of amyloid plaque aggregation and excessive negative charge resulted in loss of the alpha-helix character essential to the protein’s heme-binding function. More moderately charged proteins demonstrated that solubility was significantly enhanced in net …
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The Neuroprotective Effects of Exercise Against Menopause Induced Alterations in Alzheimer’s Disease Neuropathogenesis
… failure on the neuroinflammatory response and β-amyloid plaque deposition through the evaluation of overall microglial expression, homeostatic microglial expression, and β-amyloid plaque deposition in subregions of the hippocampus. We performed a triple immuno-fluorescence stain (Iba1, Tmem119 …
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Photobiomodulation with IR1072nm in the murine CNS: in vitro and in vivo studies
… and reduced total Aβ1-42 expression and small amyloid plaque counts (in cortex and dentate gyrus) in TASTPM mice, was observed. Overall, this thesis reveals new mechanisms of photobiomodulation with IR1072 which involves restoring cellular homeostasis for optimal functional operation of a …
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Amelioration of Alzheimer's Disease Pathology in 12-Month-Old hAPP(SweInd) Transgenic Mice After Treatment with a Cysteine Rich Whey Supplement, Immunocal®
… the number, size and density of Amyloglo stained amyloid plaques throughout the hippocampal-entorhinal cortex formation. Our findings demonstrate that Immunocal® rescues Reelin expression in vivo within the hippocampal-entorhinal cortex formation of 12-month-old transgenic hAPPSweInd mice. This …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
… by AD will quadruple by 2050. The presence of amyloid beta plaque serves a pathological hallmark for AD, since it was first described by Alois Alzheimer's in 1906. The major risk factors for developing AD are age, mutations in presenilins (PS1 and PS2), mutations in the amyloid precursor …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… is characterized by the accumulation of beta-amyloid (Aβ) peptides and amyloid plaque deposition. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), …
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Interleukin-1 (IL-1) as a potential contributor to the pathophysiology of Alzheimer's Disease
… of the Aβ precursor protein and deposition of amyloid plaques. IL-1 also activates glial cells and induces recruitment of leukocytes and peripheral macrophages to the CNS across the blood-brain barrier (BBB). When exposed to IL-1, microglia and macrophages take on a classical activation …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… islet hyperplasia and striking pancreatic amyloid plaque formation. In vitro data from cultured hepatocytes clearly showed that Pb exposure either induced the expression of genes that are required for hepatic glucose production (PEPCK, G6Pase, and PGC1-α), or blocked the ability of insulin …
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Investigation of BACE1 as a stress-induced regulator of neuronal metabolism
… focuses on studying the brain once hallmark amyloid plaque and neurofibrillary tangle pathologies have presented. However their appearance is extremely end stage and to date, any therapeutic interventions aimed at alleviating them having failed to halt symptoms progression. It may therefore …
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Optical-Resolution Photoacoustic Microscopy
… of OR-PAM for transcranial monitoring of amyloid plaque growth in an AD mouse model.
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… mitochondrial biogenesis precedes brain plaque formation, neuronal death and memory deficits B) autophagosomal formation is overactive and/or degradation of autophagosomes is inhibited in AD and C) deficits in mitochondrial biogenesis and autophagy occur earlier in life in the …
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Investigation of the role of BACE1 in adipocyte and immune cell function
… believe to be causative, associated with AD is amyloid plaque formation. Amyloid plaques occur as an aggregated form of amyloid peptides whose formation is dependent upon cleavage by an aspartyl protease named BACE1 (β-site amyloid precursor protein cleaving enzyme 1). This enzyme is the …
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The Clinical Determinants of Plasma β-amyloid and Its Association with Structural and Functional Vascular Changes
<b>Background</b>: β-amyloid plaque deposition is a pathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, β-amyloid has also been shown to possess direct vasoactive properties and increased plasma β-amyloid has been associated with endothelial dysfunction in …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
… lesions, one of which is the accumulation of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of early-onset Alzheimer's disease, but factors that modulate the risk and onset for the more common …
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