Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"amyloid fibrils"”.
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Thermodynamic Characterisation of Amyloid Fibrils
Amyloid fibril related diseases include dementia, Alzheimer’s disease and Parkinsons disease and pose an increasingly large burden to global healthcare, due to the presence of an ageing population. Despite many healthcare advances, amyloid fibril diseases remain largely untreatable, with only …
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Unzipping Amyloid Fibrils: How a Novel Calcium-Binding Protein, NUCB1, Prevents the Formation of Amyloid Fibrils
… we also established novel and unique anti-amyloidogenic functional ability of sNUCB1. We show that Ca<sup>2+</sup>-free sNUCB1 can inhibit fibril formation by highly amyloidogenic human Islet Amyloid PolyPeptide (hIAPP) and Amyloid-β 42 (Aβ42) peptides, as relevant to Type-2 Diabetes and …
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Ligands as Structural Probes for Amyloid Fibrils
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Smart Nanomaterials from Repeat Proteins and Amyloid Fibrils
… components for protein-based materials are amyloid fibrils and tandem repeat proteins. Amyloid fibrils are exceptionally strong, tough, highly-ordered structures that self-assemble from a wide range of simple building blocks. Meanwhile, tandem repeat proteins are a class of proteins that act …
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Enhancement Of Ebola Virus Infection By Seminal Amyloid Fibrils
… factors influencing this phenomenon are known. Amyloid fibrils present in healthy individuals’ semen have been suggested to be a host factor that aids in sexual transmission of viruses including HIV-1. To understand if seminal amyloid fibrils increase infection by Ebola virus, a recombinant …
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Structural studies of amyloid fibrils using solid-state NMR
… of solid-state NMR techniques and application to amyloid fibrils are presented. In addition, a new method of selective inversion based on chemical shift anisotropy is presented. An improved method for highly accurate distance measurement across parallel [beta]-sheets in amyloid fibrils has been …
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THE ROLE OF BACTERIAL AMYLOID FIBRILS IN ESCHERICHIA COLI COMPLEMENT RESISTANCE
… to the complement system. The bacterial amyloid fibril, curli, functions in bacterial adherence and the formation of biofilm. Curli-producing parental and curli-deficient mutant E. coli was compared in its survival to human complement, using in vitro serum sensitivity assays. Results …
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Whey and soy amyloid fibrils as a novel iron delivery nanosystem
Made available in DSpace on 2021-03-05T21:45:39Z (GMT). No. of bitstreams: 3 LOPEZBARRERA-DISSERTATION-2020.pdf: 4739947 bytes, checksum: 3a81506eaeeb66965bb5969148fe29a6 (MD5) LICENSE.txt: 4216 bytes, checksum: 2137c615d49ed126107fc5db0021ee66 (MD5) PROQUEST_LICENSE.txt: 4562 bytes, checksum: …
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Studies of Structure, Dynamics, and Interactions of Amyloid Fibrils by Magic Angle Spinning Solid State NMR
Amyloid fibrils are a large group of aggregates formed mainly by proteins and peptides. Lots of them are cytotoxic and causes of dozens of diseases, e.g. Alzheimer’s disease and Type II diabetes. Although the structures of amyloid fibrils contain important information of biochemistry and pathology …
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Insulin based analogs HLVEALYLV and LVEALYLV to inhibit the formation of amyloid fibrils in beta cells
<p>Human islet amyloid polypetide (hIAPP) is a 37 amino acid peptide, co-secreted along with insulin in the islets of Langerhans of pancreatic beta cells. Aggregation of hIAPP fibrils is believed to be toxic to beta cells and responsible for beta cell dysfunction and death associated with type 2 …
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Solid state nuclear magnetic resonance methodology and applications to structure determination of peptides, proteins and amyloid fibrils
… peptide fragment 105-115 of transthyretin in an amyloid fibril is investigated.
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Dynamic Measurements with Scanning Probe Microscopy: Surface Studies Using Nanostructured Test Platforms of Metalloporphyrins, Nanoparticles and Amyloid Fibrils
… materials at the nanoscale. Samples of designed amyloid proteins were characterized ex situ using scanning probe microscopy. The progressive growth and fibrillization of amyloid â over extended time intervals was visualized with high resolution using AFM.
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Protein MAS NMR methodology and structural analysis of protein assemblies
… peptides and proteins in crystalline form to amyloid fibrils and whole bacterial organelles are reported. The methods presented include novel pulse sequences and optimized pulse sequence elements, experimental approaches designed for multiple-spin systems, a protocol for efficient sequential …
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Pressure Driven Desalination Utilizing Nanomaterials
… project is to prepare hybrid membranes with amyloid fibrils intercalated with graphene oxide sheets. The addition of protein amyloid fibrils expands the interlayer spacing between graphene oxide nanosheets and introduces additional functional groups in the diffusion pathways, resulting in …
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Ensemble modeling of [beta]-sheet proteins
… transmembrane P-barrel proteins and amyloid fibrils. For these we advance the state-of-the-art in structure prediction, mutational analysis, and sequence alignment. Further, we have collaborated to apply these methods to open scientific questions about amyloid fibrils and bacterial …
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Investigating the Phase Behaviour of the Alzheimer’s Amyloid-β Peptide
… aggregation of proteins. The aggregation of the amyloid-β peptide (Aβ) into amyloid plaques is a hallmark in the aetiology of AD. However, the exact nature of the association between AD and Aβ aggregation is not fully understood. Quite generally, the aggregation of proteins into amyloid fibrils …
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Amyloid fibril structure of peptides and proteins by magic angle spinning NMR spectroscopy and dynamic nuclear polarization
Amyloid fibrils are insoluble, non-crystalline protein filaments associated with a number of diseases such as Alzheimer's and Type Il diabetes. They can have a functional role in different organisms and many proteins and peptides have been found to form amyloid fibrils in vitro. We have used magic …
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COMPUTATIONAL MODELLING OF PROTEIN FIBRILLATION WITH APPLICATION TO GLUCAGON
… method to model the steric zipper of amyloid fibrils (FibPreditor) is developed. The method generates an ensemble of structures for the steric zipper by a number of geometric operations and presents the most energetically favorable candidates as models of steric zipper. The method is …
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Amyloid Fibril Nucleation In Reverse Micelles
The 40-residue amyloid beta protein (Abeta) is the unstructured cleavage product of a common membrane protein that is produced in large quantities, but normally cleared from the brain before it exerts any apparent toxicity. Under some conditions, however, it undergoes a conformational change and …
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