Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"amyloid beta peptides"”.
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… we identified a significant increase in amyloid beta -peptides. Protein quantification of apolipoprotein E (ApoE) a protein that has been associated with the development of Alzheimer's disease, demonstrated a 5-15 fold increase in symptomatic transgenic mice. Ablation of ApoE in alpha …
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Immunotherapy for Alzheimer’s Disease: IVIg Delivery to the Hippocampus in a Mouse Model of Amyloidosis
… and pathologies, which include toxic amyloid beta peptides (Aβ) and tau. To date, there is no cure for AD and therapies are only symptomatic. A Phase III clinical trial using intravenous immunoglobulins (IVIg) - natural antibodies collected from the plasma of healthy blood donors and …
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Role Of The Alzheimer's Amyloid Precursor Protein In High Fat Diet Induced Obesity And Regulating Macrophage Phenotype
<p>Amyloid precursor protein (APP) derived amyloid beta peptides have been extensively investigated in Alzheimer's disease pathology of the brain. However, the function of full length APP in the central nervous system remains unclear. Even less is known about the behavior of this ubiquitously …
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Microfluidics and chemical kinetics to analyse protein interactions, aggregation, and physicochemical properties
… and DNA replication. However, some proteins and peptides might become harmful to living organisms; for example, their abnormal aggregation causes neurodegenerative disorders including Alzheimer disease (AD). One of the causes of AD is the presence of amyloid beta peptides Aβ(1-42), Aβ(1-40), …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… low molecular weight compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight (LMW) compounds capable of interacting with soluble Abeta may be able to modulate/inhibit the Abeta aggregation process and serve …
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Investigating nutrient excess and endothelial dysfunction: a role for BACE1 and amyloid?
… <br/><br/>Nutrient excess increases amyloid beta peptides (Aβ), which are produced in varying lengths by beta-site APP cleaving enzyme 1 (BACE1). Increased circulating Aβ42 levels is reported to promote ED, by reducing NO bioavailability, suggesting a role for Aβ in the pathogenesis …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… behavioral problems resulting from a build-up of amyloid-beta (Aβ) plaques in the brain. The degree of neuropathology is partially related to apolipoprotein E (apoE), a fat-binding protein involved in transporting cholesterol to neurons. The APOE gene, which codes for the production of apoE, has …
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Iron Dysregulation and Inflammation in Alzheimer’s Disease
… of which can promote the increased production of amyloid precursor protein (APP). We have measured different pools of brain iron in transgenic iron regulatory protein 2 knockout (IRP2-/-) mice in the early stages of neurodegeneration and in affected brain regions from AD patients at different …