Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"amyloid aggregates"”.
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Development of amphiphilic compounds as therapeutic and diagnostic agents targeting amyloid aggregates for Alzheimer’s Disease
This Dissertation was approved for publication on 2023-07-12 at 15:07.
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Investigations on the structure-toxicity relationship of different alpha-synuclein aggregates associated with Parkinson's disease
… is preceded by the formation of alpha-synuclein aggregates denoted Lewy bodies and neurites. Due to their potential value for the understanding of Parkinson’s disease (PD) and the development of effective treatments, a number of mouse models of PD have been developed. A particular PD model, …
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Prion biology in the context of bacteria
Prions are infectious amyloid aggregates first described in the context of mammalian neurodegenerative diseases collectively known as the transmissible spongiform encephalopathies. Prions have also been uncovered in yeast, where they function as protein-based units of heredity that confer unique …
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Polymorphism of Protein Condensates
… such as Alzheimer’s, Parkinson’s, familial amyloid poly neuropathy (FAP), Huntington’s, type-II diabetes, etc. Common aspect of all protein aggregation diseases is the altered protein conformation known as partially unfolded amyloidogenic intermediate that is capable of assembly into amyloid …
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Synthesis And Characterization Of New Gd3+-Containing Complexes As Potential Targeted Contrast Agents For Magnetic Resonance Imaging
… research described in this thesis, myelin and Β-amyloid aggregates were selected as targets because they are important in diagnosing neurological diseases. The myelin-targeted complexes were designed to mimic the structural features of a known myelin-specific histology stain, and ex vivo …
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Molecular level characterisation of apolipoprotein A-I aggregation leading to fibrils comprising of both α-helical and β-sheet structures
Amyloidosis is defined as the misfolding of native proteins into insoluble fibrils that are deposited within tissues and extracellular organs. 30+ structurally and sequentially unrelated proteins have the ability to form amyloid aggregates, all of which contain characteristic features. ApoA-I, the …
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Methods for study and manipulation of protein self-assembly
The self-assembly of soluble proteins into amyloid aggregates is a mechanism which can be observed in processes that are functional or disease-associated. The resulting fibrillar structures can be formed from a variety of different proteins, but all share a β-sheet rich architecture and a variety …
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Biomechanical structure-function relationships of collagen tissues, B Cell membranes, and amyloid fibers
… 1 mm), B lymphocyte membranes (~ 1 [mu]m), and amyloid protein fibers (~ 1 nm). The initial portion of this thesis addresses the mechanics of fibrous collagen tissues such as ligaments, tendons, and pericardium that serve as load bearing components in biological systems. A novel micromechanical …
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Investigating the Electrostatic Properties and Dynamics of Amyloidogenic Proteins with Polarizable Molecular Dynamics Simulations
Amyloidogenic diseases, such as Alzheimer's disease (AD) and Type II Diabetes (T2D), are characterized by the accumulation of amyloid aggregates. Despite having very different amino-acid sequences, the underlying amyloidogenic proteins form similar supramolecular fibril structures that are highly …
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Pathogenesis of Neurodegenerative Diseases via Templated Recruitment
… is the deposition of filamentous protein aggregates in the central nervous system (CNS), including neurofibrillary tangles (NFTs) composed of tau, and Lewy bodies (LBs) consisting of α-synuclein (α-syn), which are the hallmark lesions of Alzheimer's disease (AD) and Parkinson's disease …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… protein tau misfolds and accumulates into amyloid inclusions in a diverse class of diseases called tauopathies. A growing body of biochemical and structural literature has now confirmed that tau takes different disease-specific aggregate conformations, which then propagate throughout the …
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Next-generation fluorophores for single-molecule and super-resolution fluorescence microscopy
… synthetic fluorescent probes for the study of amyloid protein aggregates implicated in neurodegenerative diseases. This includes a study of the photophysical and binding properties of a novel fluorophore library based on the amyloid dye Thioflavin-T. Following on from this, is the presentation …
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Characterisation and Detection of P53 Aggregates
… multiple aggregation-prone regions and can form amyloid aggregates. Some mutants of the p53 protein, such as the R248Q mutant, exhibit higher aggregation propensity than the WT. P53 aggregation is associated with loss-of-function, gain-of-function, and dominant-negative effects of the protein and …
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Role of Whey Protein Amyloid and Amyloid-Like Aggregates in Film Formation
… Umstrukturierung von Proteinen zu funktionellen amyloiden und amyloid-artigen Aggregaten durch thermische Behandlung im sauren Milieu führt zu verbesserten Eigenschaften dieser. Dadurch werden vorteilhafte Einsatzmöglichkeiten in Lebensmittelsystemen mit oberflächenaktiver Relevanz ermöglicht. …
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Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
… characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative diseases. However, more recent work has begun to suggest that the formation of ordered inclusions serves a …
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Lessons from Tau RT–QuIC: Structure, Kinetics, and Drug Discovery
… of dementia cases worldwide. Cryo–EM studies of amyloid filaments isolated from human brains have revealed that distinct tau conformers are associated with different diseases. These findings suggest a hierarchical classification of tauopathies based on filament structure. Disease–specific …
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Spectroscopic investigations on the molecular motions and solution chemistry of the medicinal pigment curcumin.
… that there is an elevated level of Cu(II) in amyloid plaques and tumours. In addition, curcumin has the ability to damage the DNA of cancer cells in the presence of Cu(II), which leads to apoptosis. Furthermore, the tautomerisation of curcumin is essential for the binding of amyloid …
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Development of Novel Molecular Imaging Contrast Agents for Detection of Oxidative Stress
… interaction between oxidative stress and protein aggregates. To scrutinise this relationship, both bulk and single-molecule fluorescence imaging methods were used to assess the capability of novel bifunctional fluorescence dyes to localise the presence of the two putative disease-causing species, …
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Development of multifunctional compounds for the modulation and detection of amyloid beta species
… Alzheimer’s dementia currently. The presence of amyloid plaques and neurofibrillary tangles in the brain is the hallmark of AD. Amyloid β (Aβ) peptides, the main component of amyloid plaques, are formed from the cleavage of amyloid precursor protein (APP) by β- and γ-secretases. The main …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
… of polypeptide chains, however, in some cases aggregates can also be linked covalently. The process of aggregation proceeds via a multi-step mechanism: First, the monomeric peptide self-associates to oligomeric structures, and these can form nucleating species which then further elongate to …