Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"amyloid β-peptide (Aβ)"”.
-
Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention
… remains a mystery, it has become clear that the amyloid β-peptide (Aβ) is central to disease pathogenesis. The aggregation and deposition of this peptide in the brain is known to give rise to the hallmark lesions associated with Alzheimer's disease, but its exact mechanism of toxicity remains …
-
Small Molecule Binding to Disordered Proteins
… the interaction of a drug-like molecule with a peptide from an oncogenic transcription factor, c-Myc, in Chapter 2. I observed this interaction to be of entropic nature, and characterise the binding at the atomic level using simulations restrained with NMR data. The binding is extremely dynamic, …
-
Mitigating protein aggregation to reduce the toxicity inherent to Parkinson’s and Alzheimer’s diseases
Protein deposition in the form of amyloid fibrils is the hallmark of more than 40 human pathologies, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Misfolded protein oligomers formed as intermediates during the aggregation process have been strongly implicated in the onset and …
-
Investigating the Phase Behaviour of the Alzheimer’s Amyloid-β Peptide
… aggregation of proteins. The aggregation of the amyloid-β peptide (Aβ) into amyloid plaques is a hallmark in the aetiology of AD. However, the exact nature of the association between AD and Aβ aggregation is not fully understood. Quite generally, the aggregation of proteins into amyloid fibrils …
-
Investigating the Electrostatic Properties and Dynamics of Amyloidogenic Proteins with Polarizable Molecular Dynamics Simulations
Amyloidogenic diseases, such as Alzheimer's disease (AD) and Type II Diabetes (T2D), are characterized by the accumulation of amyloid aggregates. Despite having very different amino-acid sequences, the underlying amyloidogenic proteins form similar supramolecular fibril structures that are highly …
-
Applications of Focused Ultrasound for Reducing Amyloid-β in a Mouse Model of Alzheimer's Disease
… that FUS can facilitate a rapid reduction in amyloid-β peptide (Aβ) pathology in a mouse model of AD. Firstly, FUS was used to enhance delivery of an antibody directed against Aβ, which aggregates and forms extracellular plaques. FUS mediated the delivery of antibodies to the targeted right …
-
Insights into Mechanisms of Amyloid Toxicity: Molecular Dynamics Simulations of the Amyloid andbeta-peptide (Aandbeta) and Islet Amyloid Polypeptide (IAPP)
Aggregation of proteins into amyloid deposits is a common feature among dozens of diseases. Two such diseases that feature amyloid deposits are Alzheimer's disease (AD) and type 2 diabetes (T2D). AD toxicity has been associated with the aggregation and accumulation of the amyloid β-peptide (Aβ); Aβ …
-
Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
… from the accumulation and deposition of the amyloid-β peptide (Aβ) and the aggregation of hyperphosphorylated tau protein, respectively. Aβ is formed upon sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases and is secreted extracellularly. The accumulation of …
-
Restoring the balance in the kinetic network of Aβ aggregation as a drug discovery strategy for Alzheimer’s Disease
… associated strongly with the aggregation of the amyloid-β peptide (Aβ). Even though a variety of strategies has been developed towards inhibiting the aggregation of Aβ, no disease-modifying treatment has so far reached the clinic. This failure is in part due to i) an incomplete knowledge of the …