Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"amylin"”.
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Rational Design and Application of Antibodies for Amylin and Amyloid Beta
Misfolded proteins and polypeptides such as amylin (islet amyloid polypeptide, IAPP) and amyloid beta are associated with numerous age-related pathological conditions such as Alzheimer's, Parkinson's, and type II diabetes, but effective treatments for these diseases are currently lacking. …
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Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… are exposed to different levels of metabolites. Amylin, or islet amyloid polypeptide (IAPP), is a 37 amino-acid peptide hormone, that is co-secreted with insulin from pancreatic β-cells in response to nutrient stimuli. Amylin dyshomeostasis occurs in T2DM. Initially, as peripheral insulin …
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Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
<p>Amylin receptor antagonist AC253 is a 24-amino acid peptide that provides neuroprotection against amyloid beta (Aβ)-induced cell death and toxicity. Additionally, AC253 has been shown to improve spatial memory in mouse models of Alzheimer’s disease (AD). Screening of short overlapping fragments …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
… islet amyloid polypeptide (hIAPP), also known as amylin, is the main constituent of the amyloid deposits present in approximately 95% of people with type 2 diabetes. Amylin aggregates into oligo-/polymeric sheet structures which are considered to be cytotoxic to pancreatic -cells. Inhibiting the …
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Discovery and Mechanisms of Small Molecule Amyloid Formation Inhibitors
… understanding key aspects relating to the anti-amylin amyloid activities associated with both individual and broad groups of small molecule amyloid inhibitors. A main observation was the important role that the catechol functional group plays in modulating and preventing amyloid formation. In …
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Insulin based inhibitors of human islet amyloid polypeptide (hIAPP) and their effect on hIAPP- mediated membrane damage in type 2 diabetes mellitus
<p>Amylin (Islet Amyloid Polypeptide, IAPP) is a 37 amino acid polypeptide, co-secreted with insulin from pancreatic beta cells, that plays a role in the damage of cell membranes by forming amyloid fibrils in Type 2 diabetes. Insulin has been found to inhibit hIAPP (Human Islet Amyloid Polypeptide) …
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Sites of interaction between calcitonin-family peptides and their receptors
… of peptides comprises calcitonin, amylin, calcitonin gene-related peptides (CGRPs), adrenomedullin (AM) and AM2. Their receptors are calcitonin receptorlike receptor (CLR) or calcitonin receptor (CTR) and receptor activity-modifying protein (RAMP) complexes. RAMP1 with CLR …
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Membrane fragmentation by a 20-29 fragment of human islet amyloid polypeptide and rat amyloid polypeptide
… Amyloid Polypeptide (hIAPP, also known as human amylin) is believed to play a crucial role in this biological process. Previous studies have shown that hIAPP forms small aggregates that kill β-cells by disrupting the cellular membrane. In this study we report membrane fragmentation by hIAPP20-29 …
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Synthesis and dye leakage assay of human and rat islet amyloid polypeptide 10-19 and insulin 14-18
<p>Islet amylin polypeptide (IAPP) is co-secreted along with insulin in the pancreatic islets of Langerhans. During type 2 diabetes mellitus, human IAPP (hIAPP) fibrilizes to form amyloid deposits that are found post-mortem in more than 95% of people with the disease. Rodents do not suffer from …
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Design and Synthesis of Mitochondrial Uncouplers for the Treatment of Mitochondrial Dysfunction
… pyridine cores that are efficacious in a Gubra-Amylin (GAN) mouse model of MASH. We also disclose a novel prodrug approach for BAM15 by utilizing a glyoxal cage. In doing so, we aim to achieve an improved pharmacokinetic property. These developments showcase the potential use of a mitochondrial …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… adiponectin and cells assayed for insulin and amylin (to investigate the role of amylin in insulin secretion). Also the cells were collected and mRNA extracted from these cells, reverse transcription PCR carried out to find out the role of protein phosphatase 1 (PP-1) in the effect of leptin on …
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… I have shown that <em>IAPP</em>, which encodes amylin, a 37-amino acid peptide functions as a tumor suppressor in p53-deficient cancers. IAPP functions through the calcitonin and RAMP3 receptors to limit glucose uptake and reduce glycolysis in the cancer cells resulting in ROS accumulation and …
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Role of aromatic pi-stacking on the aggregation of human islet amyloid polypeptide (hIAPP)
<p>Human islet amyloid polypeptide (hIAPP) is secreted in the β-cells of the pancreas, which also secretes insulin. In type 2 diabetes mellitus, hIAPP undergoes self-aggregation, forming fibrils. This self-aggregation is cytotoxic and is thought to be linked to type 2 diabetes mellitus by causing …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
… ASCs also did not express proinsulin, amylin, and C-peptide. Therefore the insulin detected by the guinea pig antibody appears not to be genuine, and may result from the previously unreported non-specific binding of the anti-insulin antibody to a related protein. Phenotyping of the …
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The Molecular Interaction Between Type Ii Diabetes and Alzheimer’S Disease Through Cross-Seeding of Protein Misfolding
<p>With the population of the world aging, the prominence of diseases such as Type II Diabetes (T2D) and Alzheimer’s disease (AD) are on the rise. In addition, patients with T2D have an increased risk of developing AD compared to age-matched individuals, and the number of AD patients with T2D is …