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Showing 1 to 19 of 19 for “"amphiphilicity"”.
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Janus Particles at the Air-Water Interface: Single particle behavior, particle-laden interfaces, and implications for self-assembly
… is of particular interest as the anisotropy and amphiphilicity of these particles can be tuned in order to drive self-assembly and thus be used to template microstructures in a bottom up fashion. The ability to pattern particles at interfaces has a multitude of applications such as achieving …
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Synthesis of novel asymmetrically substituted phthalocyanines
… examined different methodologies for imparting amphiphilicity to phthalocyanine-based photosensitizers. Boron subphthalocyanines are the lower homologs of phthalocyanines and the reactivity of boron subphthalocyanines allows them to react with 1,3-diiminoisoindolines in a Kobayashi ring …
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Anticancer a-helical peptides and their structure / function relationships underpinning their interactions with tumour cell membranes
… net charge, mean hydrophobicity (<H>) and amphiphilicity (<I'H>) of the peptides did not show a linear correlation with the toxicity, they may help increase efficacy in the case of some tumour cell lines. Three-dimensional clustering using net charge, <H> and <p a> was carried out using the …
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DE NOVO DESIGN OF ANTIMICROBIAL PEPTIDES FOR APPLICATION AS ANTI-INFECTIVE AGENTS
… alpha-helical peptides with idealised facial amphiphilicity, is proposed. In doing so, we demonstrate that the adoption of such systematic design principles, in the optimisation of short synthetic AMPs, could facilitate the development of safe and effective novel peptide therapeutics for …
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Synthesis, spectroscopic, and electrochemical properties of 3d metal and ruthenium complexes with phenolate and catecholate ligands
… of differentiated topologies to extend amphiphilicity and redox behavior, and the introduction of photosensitizing properties into electroactive metallosurfactant precursors. In an attempt to enhance the redox response of our current phenolato-based ligand scaffolds, rich multielectronic …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… or perfluorocarbon sidechains provides amphiphilicity to produce the multimodal self-assembling micelles. Additionally, encapsulation procedures for chemotherapeutic agents, doxorubicin and paclitaxel, have been established.
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Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas
… positive charge, α-helical structure and strong amphiphilicity. In this study, QUB-2428, a peptide related to the plasticins from the dermaseptin superfamily, was isolated from the skin secretion of the Central American Red-eyed Leaf Frog, Agalychnis callidryas. A cDNA library was constructed by …
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Synthesis of Polysaccharide-based Biomaterials for Drug Delivery
… methods. The products showed manipulated amphiphilicity and excellent thermostability, exhibiting potential application in ASDs. We anticipate that these strategies will benefit future polysaccharide chemistry research and permit synthesis of a broad variety of more functional biomedical …
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Parallel effects of signal peptide hydrophobic core modifications on cotranslational translocation and posttranslational cleavage by purified signal peptidase
… but correlated inversely with core amphiphilicity. Deletion at the N-terminus of the core caused a significant decrease in signal activity while deletions at the C-terminus had little effect. Signal activity improved as the position of the pair-wise deletion moved from the N-terminus …
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Investigation into the structure function relationship of the membrane interaction of amphiphilic alpha helical antimicrobial peptides
… hydrophobicity, <H> (range -0.8 to +0.7) whilst amphiphilicity (measured by the hydrophobic moment, <jAH>) ranged from 0.2 to 1.1. A statistically significant negative correlation between <pH> and <H> was noted for each group of a-AMPs and this may relate to the amphiphilic balance required for …
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Dendronized Amphiphilic Copolymers Synthesized from Methacrylate Derivatives as Potential Topical Microbicides
… the pursuit of effective antimicrobial agents: amphiphilicity, multiple anionic functional groups, a polymer backbone, and aqueous solubility. Additionally, biological selectivity (e.g. cytotoxicity) is expected to be tunable through the control of molecular weight, alkyl chain length (n*), …
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Cubosome and Hexosome Microparticles: Shape, Rheology, and Templating
… with unique micron-scale geometric shapes. The amphiphilicity of particles allows incorporation of various organic monomers. Photopolymerization in the lipid templates creates polymerized particles preserving the shapes of cubosomes and hexosomes. Particle shapes are controlled by varying the …
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Cationic amphiphilic synthetic macromolecules with superior antibacterial activity
… hydrophobic side groups, molecular weight, and amphiphilicity on its activities. </p> <p>This dissertation investigation has led to one of the most promising synthetic polymer systems reported till today for antimicrobial applications. </p>
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Development of Core-Shell Polymeric Nanostructures for Delivery of Diagnostic and Chemotherapeutic Agents
… have been formed by electrostatic condensation. Amphiphilicity of the complexes was introduced into the shells by incorporating a hydrophobic poly(propylene oxide) segment into the block copolymer. The resulting particles have an average hydrodynamic diameter of ~ 200 nm and contain up to 30-40 % …
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Design and Synthesis of Complex and Fluorescent Labeled Cellulose-Based Derivatives for Orally Administered Drug Delivery Systems
… enhancement, possessing the appropriate amphiphilicity to increase drug concentration in this study, supported by the similarity of the polymer and drug solubility parameters. I was further able to confirm via polarized light microscopy that advantageous nanodroplet formation occurs …
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Template-Controlled Synthesis of Magnetic/Semiconducting Nanoparticles within Amphiphilic Core-Shell Cylindrical Polymer Brushes
… because of the core-shell structure and the amphiphilicity of side chains. The amphiphilic brushes can be used as single molecular templates for the synthesis of inorganic nanoparticles, because the carboxylic acid groups (or carboxylate groups, after neutralization) in the polymer core can …
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Quantitative analysis of amphiphilic properties of membrane interactive proteins
… related to any biological role. A new measure of amphiphilicity, which takes into account the third dimension of a helix, was also developed and compared to the conventional hydrophobic moment using bootstrap and regression modelling with a categoricat predictor. From the 95% bootstrap confidence …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
The use of amorphous solid dispersions (ASDs) is an effective and increasingly widely adopted approach for solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property …
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Development of alternating amphiphilic copolymers for targeted delivery applications in cancer
… attached, including hydrophobic groups to impart amphiphilicity, targeting ligands, as well as contrast agents for imaging applications. Three major areas of investigation were addressed to develop and evaluate the performance of the proposed amphiphilic alternating copolymers: (1) backbone …