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Showing 1 to 20 of 27 for “"amphiphilic block copolymers"”.
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Synthesis and self-assembly of multiple thermoresponsive amphiphilic block copolymers
… the self-assembly of multi thermoresponsive block copolymers in dilute aqueous solution was investigated by a combination of turbidimetry, dynamic light scattering, TEM measurements, NMR as well as fluorescence spectroscopy. The successive conversion of such block copolymers from a …
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Synthesis of Amphiphilic Block Copolymers for Use in Biomedical Applications
… in this thesis focuses on the synthesis of three amphiphilic block copolymer systems containing poly(ethylene oxide) (PEO) blocks. The polymer systems were developed for use in biomedical applications. The first of these is a series of poly(ethylene oxide-b-oxazoline) (PEO-b-POX) diblock …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… dissertation research includes the syntheses of amphiphilic block copolymers bearing functional groups through controlled radical polymerization techniques, followed by the aqueous assembly of these block copolymer precursors to construct polymeric nanostructures with different sizes and …
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Development and study of synthetic polypeptides for biomaterial applications
… L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic polypeptide with click functionality is also investigated. Additionally, the creation of a …
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Synthesis and catalytic testing of a proline functionalized amphiphilic block copolymer
… consumed. The use of catalyst functionalized amphiphilic copolymer allows easier recovery of the catalyst at the end of the synthesis and allows for the reaction. In water, under appropriate conditions, the amphiphilic block copolymers will form micelles and allow the reaction to occur on the …
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Self-assembly behavior in hydrophilic block copolymers
Block copolymers are receiving increasing attention in the literature. Reports on amphiphilic block copolymers have now established the basis of their self-assembly behavior: aggregate sizes, morphologies and stability can be explained from the absolute and relative block lengths, the nature of the …
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Synthesis and <sup>1</sup>H-NMR characterization of amphiphilic acrylate block copolymers to investigate the effect of chain rigidity on micelle formation in solution
<p>Amphiphilic block copolymers are composed of distinct segments exhibiting different chemical properties. In solution, block copolymers may self-assemble to form micelles when triggered by a change in the environment. The effect of chain rigidity can be investigated in better detail if the …
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Block copolymer micellar thin films as templates for the production of tunable inorganic nanocluster arrays and their applications
… scale has been an active area of research. Block copolymer thin films are a subclass of' self-assembling systems that have received considerable attention due to their intrinsic nanometer feature size, their ease of synthesis, and their rich phase behavior. While block copolymer thin films …
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Engineering effective fibrocartilage replacement technologies using nanostructure-driven replication of soft tissue biomechanics in thermoplastic elastomer hydrogels
… using the melt-state self-assembly of amphiphilic block copolymers. Rigorous characterization and preliminary mechanical testing reveal that swelling of these preformed networks produce hydrogels with physiologically relevant moduli and water compositions, negligible hysteresis, …
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Fundamental studies of pH-sensitivity in polyelectrolyte multilayers
… incorporated molecules. For example, polystyrene-block-poly(acrylic acid)(PS-PAA) selectively adsorbs to the PAH-rich surfaces of PAA/PAH multilayer films thus rendering the originally hydrophilic PAH-rich regions hydrophobic. Furthermore, by using micro-patterned multilayers via ink-jet printing, …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… the bloodstream and high overall clearance rate. Amphiphilic block copolymers based on hydrophobic dendrons have shown to be a promising strategy to enhance the solubility of hydrophobic drugs, prolong circulation time, minimise non-specific uptake, and allow for specific tumour-targeting through …
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Design, Synthesis, and Characterization of Magnetite Clusters using a Multi Inlet Vortex Mixer
… of magnetite nanoparticles stabilized with an amphiphilic block copolymer. It outlines a method to design and form well-defined and colloidally stable magnetite clusters. A Multi Inlet Vortex mixer (MIVM) was used because it is a continuous process that yields particles with relatively narrow …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
Amphiphilic block copolymers consisting of poly(ethylene oxide) and poly(lactide) have great potential for formulating drug delivery systems. Our approach was to synthesize poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality …
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Self-assembly of inorganic nanoparticle amphiphiles for biomedical applications
… (NPAMs) and the use of NPAMs as building blocks to construct polymer-inorganic hybrid materials. The NPAMs are made from NPs surface-grafted with amphiphilic block copolymers (BCPs). In this way, the NPAMs synergistically combine the properties of both inorganic NPs and grafted BCPs, such …
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Synthesis and Characterization of Novel Polyethers and Polypeptides for Use in Biomedicine and Magnetic Resonance Imaging
Copolymers that contain terminal or pendent functional groups have great potential in the biomedical area due to their biocompatibility and tunable properties.1-3 In this research, two vinyl functional epoxides, vinyldimethylsilylpropyl glycidyl ether (VSiGE) and ethoxy vinyl glycidyl ether (EVGE), …
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Design and Synthesis of Supramolecular Structures for the Controlled Release of Sulfur Signaling Species
… comonomer incorporated into the core-forming block. The glass transition temperature of the core-forming block varied predictably with incorporation of the plasticizing comonomer. Accordingly, the half-life of H₂S release decreased from 4.2 h to 0.18 h with increasing core-forming block …
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Amphiphilic Poly(2-isopropyl-2-oxazoline)-block-poly(lactide) Nanoparticles as Drug Delivery Vehicles
… of water-soluble poly(2-isopropyl-2-oxazoline)-block-poly(DL-lactide) and poly(2-isopropyl-2-oxazoline)-block-poly(L-lactide) (PiPOx-b-PDLLA and PiPOx-b-PLLA) nanoparticles was obtained via Fluorescence Spectroscopy. Additionally, loading and release studies were carried out with hydrophobic …
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The multifarious self-assembly of triblock copolymers : from multi-responsive polymers and multi-compartment micelles
New ABC triblock copolymers were synthesized by controlled free-radical polymerization via Reversible Addition-Fragmentation chain Transfer (RAFT). Compared to amphiphilic diblock copolymers, the prepared materials formed more complex self-assembled structures in water due to three different …
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New block copolymers of Isobutylene by combination of cationic and anionic polymerizations
… presented in this thesis deal with the new block copolymers of isobutylene by combination of cationic and anionic polymerizations, which are new materials with numerous promising potential applications. A new method for the synthesis of tailored polyisobutylene(PIB)-based block copolymer by …
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