Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 308 for “"amphiphilic"”.
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Amphiphilic Spin Crossover Complexes
… thesis was the synthesis and characterization of amphiphilic iron(II) spin crossover complexes. The prime attention was on the self-assembly ability of the synthesized compounds and the influence of the supramolecular arrangement in the solid on the SCO behaviour. The used ligand system is based …
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Zein encapsulation of amphiphilic compounds
… compounds and control their release. Zein is an amphiphilic protein originally obtained from corn. Its film-forming and coating ability make it potentially useful as a wall material for encapsulation. Amphiphilic compounds have been recognized to form well defined microspheres by evaporation …
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Monte Carlo simulations of amphiphilic systems.
Results are presented from NVT Monte Carlo simulations of a three-dimensional lattice model of a binary mixture of solvent and surfactant chains in which free self assembly is allowed. It is demonstrated that the model exhibits a critical micelle concentration together with cluster size …
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Biomimetic Surface Coatings from Modular Amphiphilic Proteins
… a diblock motif consisting of a surface-active, amphiphilic block β-sheet domain linked to a disordered, water-soluble block with a terminal functional domain. Several types of functional domains were investigated, including sequences that act as ligands for cell surface receptors and sequences …
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Force microscopy of self-assembled amphiphilic films
Scanning force microscopy is a powerful technique to study surfaces in vacuum, air or liquids because of its nanometer spatial resolution and piconewton force resolution. The work presented here uses colloidal (steric and double layer) forces to investigate the shape of surfactant micelles on an …
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Peptide nanovesicles: supramolecular assembly of branched amphiphilic peptides
… synthesized a set of 15 and 23-residue branched, amphiphilic peptides that mimic phosphoglycerides in molecular architecture. They undergo supramolecular self-assembly and form solvent-filled, bilayer delineated spheres with 50-150 nm diameters (confirmed by TEM and DLS). Whereas weak hydrophobic …
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Gene delivery with amphiphilic lower generation polypropylenimine dendrimer
In this work a novel lower generation amphiphilic polypropylenimine (PPI) dendrimer with good aqueous solubility was developed and tested as a gene delivery agent. PPI dendrimer generation 3 (DAB-16-Am) was substituted with a low level of cetyl chains (less than 5 molar percent) by reaction with …
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Cationic amphiphilic synthetic macromolecules with superior antibacterial activity
… design, synthesis, and development of synthetic amphiphilic macromolecules with antimicrobial activity and very low hemolytic impact. Synthetic amphiphilic polymers attack bacteria directly to rupture the cell membrane through electrostatic and hydrophobic interactions. However, the toxicity of …
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Amphiphilic hyperbranched polyglycerols for industrial and biomedical applications
… and utility. Herein, we report two distinct amphiphilic HPG materials designed for applications in nanomedicine and industry. Theranostic agents have the potential to provide solutions for the detection, targeting and treatment of cancer and cardiovascular disease, two of the most prevalent …
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Crystalline frameworks self-assembled from amphiphilic DNA nanostructures
… on a new class of self-assembling DNA motifs; amphiphilic cholesterol-functionalised DNA nanostars, \emph {C-stars}. C-stars combine key advantages of all-DNA motifs and conventional amphiphilic molecules -- allowing for the preparation of expanded crystalline frameworks with tunable properties …
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Amphiphilic linear-dendritic block copolymers for drug delivery
… in a site-specific manner. In this thesis, an amphiphilic linear-dendritic block copolymer was designed, synthesized, and applied as a new polymeric drug delivery platform. First, to develop the drug delivery vehicle, an ABA dendritic-linear-dendritic block copolymer consisting of …
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Quantitative analysis of amphiphilic properties of membrane interactive proteins
… to traverse the bilayer. These may either be amphiphilic or predominantly hydrophobic (such as those found in the photoreaction centres). Such helices are distinguished by low charge densities and large mean hydrophobicities. Several hydrophobicity measures (scales) and algorithms for …
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Improved filtration membranes through self-organizing amphiphilic comb copolymers
… In this thesis, the self-organization of amphiphilic comb copolymers is employed to develop improved membranes for aqueous filtration. The use of self-assembling copolymers leads to the desired properties (surface chemistry, selectivity) without additional processing steps. One aspect of …
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Amphiphilic star polymers as solubilizing agents for environmental spearations
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Interaction of amphiphilic nanoparticles with structurally perturbed lipid membranes
… significantly decreases the insertion latency of amphiphilic gold nanoparticles into both the densely and sparsely packed leaflets. We further demonstrate using transition state analysis that the dominant mechanisms for insertion into the dense and sparse leaflets are lipid desorption and lipid …
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Synthesis and self-assembly of multiple thermoresponsive amphiphilic block copolymers
… into a hydrophobic state includes intermediate amphiphilic states with a variable hydrophilic-to-lipophilic balance. As a result, the self-organization is not following an all-or-none principle but a multistep aggregation in dilute solution was observed. The synthesis of double thermoresponsive …
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Preparation of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles for Pharmaceutical Applications
… Vesicles are formed by hydrating a thin film of amphiphilic cyclodextrin and guest molecules in buffer solution that mimics physiological conditions. The solution is subject to freeze-thaw cycles and extrusion, and the complexes are separated out via size exclusion chromatography. Dynamic Light …
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Synthesis of Amphiphilic Block Copolymers for Use in Biomedical Applications
… in this thesis focuses on the synthesis of three amphiphilic block copolymer systems containing poly(ethylene oxide) (PEO) blocks. The polymer systems were developed for use in biomedical applications. The first of these is a series of poly(ethylene oxide-b-oxazoline) (PEO-b-POX) diblock …
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