Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"amphipathic helices"”.
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Decoding the Sequence-Dependent Properties of Intrinsically Disordered Proteins
… We first investigated tau K19, which forms amphipathic helices in acidic membranes. The nature of the tau-membrane interaction mimics that of the tau-microtubule interaction as seen in cryo-EM studies, and we propose a method in which membrane mediates tau transfer to microtubules. Next, we …
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HAMP Domain and Signaling Mechanism of the Aer Protein
… The Aer HAMP domain is proposed to contain three amphipathic helices. The first amphipathic sequence (residues 207-233) was required for proper folding of the N terminus of Aer. Mutations that abolished FAD binding were clustered in the second putative amphipathic helix (residues 234-251), whereas …
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Structure and activity of human clusterin.
… non specific affinity for markedly hydrophobic/amphipathic ligands including terminal complement components, Alzheimer's disease amyloid beta (Abeta) peptides, and apo AI-HDL in addition to immunoglobulins, TGFbeta receptors, heparin and the endocytic receptor LRP2. Little is known of clusterin …
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Characterization of an Amphipathic Alpha-Helix in the Membrane Targeting and Viral Genome Replication of Brome Mosaic Virus
… This study examined the possible role of an amphipathic α-helix, helix B, in BMV 1a's membrane association. Deletion or single substitution of multiple amino acids of helix B abolished BMV 1a's localization to nuclear ER membranes. Additional reporter-based, gain-of-function assays showed …