Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"amphid"”.
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Hedgehog - like Proteins are Involved in a Novel Glia - Neuron Signalling Pathway in C. elegans
… The largest one in the animal is called the amphid and acts somewhat like a nose for the worm. Amphid neurons are integral to sensing odorants, salts, and other environmental cues that the animal needs to assess for successful feeding, reproduction, and escaping harmful conditions. In these …
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The Roles of daf-6 and Cell-Cell Interactions in Sensory Organ Morphogenesis
… the development of the Caenorhabditis elegans amphid sensory organ. Sensory organs in diverse species are often composed of neuronal sensory endings accommodated in a lumen formed by ensheathing epithelia or glia. The generation of this structure may require cell-autonomous factors that control …
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Sensory Organ Morphogenesis in Caenorhabditis Elegans
… sensory organ of Caenorhabditis elegans, the amphid, as a model system for understanding how glia form these compartments. First, by the interpretation of electron microscopy reconstructions of the developing amphid, I was able to uncover a role for daf-6/Patched, an established regulator of …
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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans
… that sensory receptive endings of the AWC amphid neurons in dauer animals remodel in the confines of a compartment defined by the amphid sheath glial cells that envelop these endings. The glia remodel concomitantly with and independently of AWC receptive endings to delimit AWC receptive …
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IGDB-2, an IG/FNIII Protein, Binds the ION Channel LGC-34 and Controls Sensory Compartment Morphogenesis in C. Elegans
… lacking. To date, the Caenorhabditis elegans amphid sensory organ has provided critical insight into some of these developmental processes. DAF-6, a Patched-related protein, was previously shown to be required in amphid glia to restrict sensory compartment size. LIT-1, a Nemo-like kinase, and …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… roles, we ablated the major glial cell of the amphid sensilla. Embryonic glial ablation did not affect neuronal survival and resulted in sensory neuron dendrites that were far too short, revealing a glial role in anchoring sensory neuron dendrites. To examine post-developmental glial roles, we …
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Molecular Mechanisms Underlying Stress-Induced Glia Remodeling in the Nematode C. Elegans
… individually ensheathed by processes of adjacent amphid sheath (AMsh) glial cells. Upon exposure to high temperature, starvation, or crowding, animals enter an alternative developmental state, called dauer, in which bilateral AMsh glia membranes surrounding the AWC neuron fuse, connecting the two …
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IR Laser-Induced Gene Expression for Tracking Development of Single Embryonic Neurons and Glia in C. Elegans
… I use this system to uncover a role for the amphid sheath glia in dendrite extension. As IR induction can be used for targeted labeling, gene expression, and ablation without the need for cell-specific drivers, this tool opens to door to high resolution systematic analyses of C. elegans …
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Understanding Chemotaxis in the Nematode Caenorhabditis elegans: From Molecules to Behavior
… elegans. My work focuses on a pair of amphid sensory neurons at the head end of the worm called ASEs. The neurons are exposed and respond to environmental chemical signals, and instruct downstream locomotory responses that cause the worm to move up or down chemical gradients. The ASE …
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The nervous system of plant-parasitic nematodes and their behaviors
Nematodes are the most abundant animals on earth. The majority of nematodes are free-living which feed on bacteria and fungi in the soil. However, some nematodes are parasitic to other animals and plants and have a huge impact on human health and agriculture worldwide. The nervous system of the …