Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"amphibian skin secretion"”.
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Discovery of bioactive peptides from amphibian skin secretion
During the long evolutionary process, amphibians have developed their unique defence mechanisms. Among these, bioactive peptides in special skin secretions produced by frogs have been considered to be one of the rich natural sources for developing new drugs in the future.<br/><br/>In this thesis, …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
In this thesis, molecular cloning techniques were used to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
Amphibian skin secretions are remarkable sources of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
The skin secretions of amphibians contain large amounts of biologically-active compounds, such as antimicrobial peptides (AMPs), anticancer peptides and trypsin inhibitors. Several kinds of AMPs, isolated and characterised from the skin of amphibians, have been studied by researchers to provide …
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Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion
Amphibians make a tight relationship between land and water as they have to protect themselves from various situations and survive by producing defensive skin chemicals, including alkaloids, proteins and peptides. In recent years, research on peptides from the skin secretion of frogs has attracted …
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Identification and functional evaluation of a Temporin peptide, QUB-1549, from amphibian skin secretion
Amphibian species are a natural source for pharmaceuticals and their skin has been an area of research which has focused on skin secretions as a reservoir of active peptides. In the present study a new temporin peptide cDNA derived from the Hylarana latouchii was subject to “shotgun cloning”. The …
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Molecular cloning, peptide synthesis and bioactive assessment of a skin defensive peptide, QUB-2658 from the skin secretion of <i>Limnonectes fujianensis</i>
In recent years, research on amphibian skin secretion peptides has become a hot topic for researchers. Antimicrobial peptides (AMPs) from amphibian skin secretion were found to have excellent broad-spectrum antibacterial activities and inhibit drug-resistant bacteria, which made AMPs a potential …
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QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
Amphibian skin secretion is one of the richest sources for antimicrobial peptides (AMPs) which have potent bioactivity and pharmaceutical value for new drug development. In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is …
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The discovery of a novel peptide, QUB-2023, from Rana amurensis
… antimicrobial peptides (AMPs) discovered in amphibian skin secretions have raised the interest of many researchers not only because of their broad spectrum of actions against many clinically-relevant microorganisms but also their superiority over conventional antibiotics.<br/><br/>This …
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A bioactive peptide from the defensive skin secretion of <i>Odorrana versabilis</i>
The skin of amphibians is rich in bioactive substances among which are those called bioactive peptides. The bioactive peptides could play a key role in new drug development. In this thesis, a bioactive peptide named QUB-1966, was isolated and characterised from the skin secretion of the Chinese …
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Identification and characterisation of a novel antimicrobial peptide from the defensive skin secretion of the Heilongjiang brown frog, Rana amurensis
… of structure and activity of peptides. The amphibian skin secretion is a huge resource for AMPs. In this study, a novel AMP (QUB-2944) from the defensive skin secretion of the Heilongjiang Brown Frog, Rana amurensis, has been identified and characterised. The nucleotide sequence and …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
… field of BBIs have led to a renewed interest in amphibian skin-derived BBIs which have a much shorter chain and remarkable inhibitory effect. <br/><br/>In this study, a bioactive peptide, QUB-1904, was discovered from skin secretion of Pelophylax esculentus by shotgun cloning of a novel …
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Assessing bioactivity of peptide QUB2003 from the skin secretion of the Waxy monkey tree frog Phyllomedusa sauvagii
Frog skin acts as a first line barrier of defence in amphibians, is important in their daily lives and is having significant implications in current biomedical science research. According to this research, amphibian skin secretion is a rich source of bioactive materials, including antimicrobial …
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A bioactive peptide, QUB-2048, from the defensive skin secretion of Phyllomedusa tomopterna
Amphibian skin is a biochemically, morphologically and physiologically complex organ which is responsible for the survival and defence of amphibians. Amphibian skin secretion is deemed as a reservoir of bioactive compounds and antimicrobial peptides (AMPs) are among the most attractive of these. …
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Identification and functional study of a novel antimicrobial peptide, QUB-2014, from the skin secretion of the frog, Phyllomedusa tomopterna
Amphibian skin secretion contains various bioactive compounds. Among these, antimicrobial peptides (AMPs) are vitally important as they protect amphibians from the attack of microorganisms. Some studies showed that AMPs are considered the new potential antibiotic candidates for humans and these …
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Identification, Molecular Cloning and Functional Characterisation of Novel Bioactive Peptide Drugs from Amphibian Skin Secretions
Skin secretions of amphibians, which contain a large amount of bioactive compounds, play an essential role in their survival. For instance, some toxic or irritant secretions can protect them against predators. Due to the pharmacological and bioactive characteristics of the components in amphibian …
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Identification, characterization and bioevaluation of a bioactive peptide from the skin secretion of the Chinese forest frog
… their special membrane antibacterial mechanism. Amphibian skin secretion was found to be an ideal source of antimicrobial peptides, which is worthy of further study.<br/><br/>In this study, the skin secretions of the Chinese forest frog (Rana chensinensis) were collected in a mitigating …
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Novel bioactive peptides from the defensive skin secretion of Phyllomedusinae frogs
Amphibian skin secretion contains a variety of bio-components, of which bioactive peptides are predominant. They produce such peptides to protect themselves from the threats in their environment like predatory attack and microorganism invasion. Antimicrobial peptides (AMPs) act as the first line of …
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Identification, characterisation and design of bioactive peptides from Chinese frogs
Antimicrobial peptides from amphibian skin secretions have become candidates as replacements for conventional antibiotic therapies. Temporin is an AMP type found in skin secretions of frogs from the family Ranidae, In Chapter 3, a novel temporin family peptide, QUB1434, was identified from …
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