Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"amphibian skin"”.
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Discovery of bioactive peptides from amphibian skin secretion
During the long evolutionary process, amphibians have developed their unique defence mechanisms. Among these, bioactive peptides in special skin secretions produced by frogs have been considered to be one of the rich natural sources for developing new drugs in the future.<br/><br/>In this thesis, …
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Investigation of insulinotropic and cytoprotective effects of selected amphibian skin peptides
… have demonstrated the anti-diabetic effects of amphibian peptides such as tigerinin-1R, magainin-AM2, and alyteserin-2a. However, the mechanisms underlying their actions are not yet fully understood. Moreover, the protective effect of this study aims at the confirmation of the in vitro and in …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
In this thesis, molecular cloning techniques were used to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF …
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Assessing sources of variation in amphibian skin thickness: ecological and evolutionary implications
The skin is the largest organ of the body and provides many functions. Among tetrapod vertebrates, amphibian skin is semi-permeable and responsible for a greater proportion of water absorption and gas exchange. Myriad factors affect the physiological performance of amphibian skin. Morphological …
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Assessing Diversity, Culturability and Context-dependent Function of the Amphibian Skin Microbiome
… documented around the world. Global losses of amphibians provide evidence of this, especially those associated with chytridiomycosis, a lethal skin disease caused by the fungus Batrachochytrium dendrobatidis (Bd). Amphibian skin can harbor diverse bacterial communities that, in some cases, can …
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Discovery, structural characterisation and targeted engineering of bioactive peptides from amphibian skin secretion
Amphibian skin secretions are remarkable sources of novel bioactive peptides. Among these, the antimicrobial peptides (AMPs) have demonstrated an outstanding efficacy in killing microorganisms via a general membranolytic mechanism, which may offer a prospect of solving specific target driven …
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Molecular cloning, structural characterisation and functional study of peptides from amphibian skin secretion
The skin secretions of amphibians contain large amounts of biologically-active compounds, such as antimicrobial peptides (AMPs), anticancer peptides and trypsin inhibitors. Several kinds of AMPs, isolated and characterised from the skin of amphibians, have been studied by researchers to provide …
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Molecular cloning, structural characterisation and functional study of bioactive peptides from amphibian skin secretion
Amphibians make a tight relationship between land and water as they have to protect themselves from various situations and survive by producing defensive skin chemicals, including alkaloids, proteins and peptides. In recent years, research on peptides from the skin secretion of frogs has attracted …
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Identification and functional evaluation of a Temporin peptide, QUB-1549, from amphibian skin secretion
Amphibian species are a natural source for pharmaceuticals and their skin has been an area of research which has focused on skin secretions as a reservoir of active peptides. In the present study a new temporin peptide cDNA derived from the Hylarana latouchii was subject to “shotgun cloning”. The …
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Identification, Molecular Cloning and Functional Characterisation of Novel Bioactive Peptide Drugs from Amphibian Skin Secretions
Skin secretions of amphibians, which contain a large amount of bioactive compounds, play an essential role in their survival. For instance, some toxic or irritant secretions can protect them against predators. Due to the pharmacological and bioactive characteristics of the components in amphibian …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
… peptides with potent bioactivity from frog skin secretions and performing functional experiments on them. In chapter 3, DRP-AC4, a novel dermaseptin family peptide was isolated and identified. DRP-AC4 possesses broad-spectrum antimicrobial activity and inhibits the proliferation of a wide …
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Bioactivity evaluation and structural modification of Bowman-Birk type protease inhibitory peptides from amphibian skin secretions
Frog skin can produce secretions containing complex chemical components in a holocrine manner. On the one hand, these chemical molecules play an important role in the physiological functions and defence systems of frogs. On the other hand, they provide the main source for the development of new …
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Identification and bioactivity evaluation of an amphibian skin Bowman-Birk-like trypsin inhibitor from Hylarana nigrovittata
… in their living environment, granular glands of amphibian skin can produce various compounds, especially peptides and proteins, which are useful for preventing bacterial and fungal infections. Among these bioactive compounds, serine protease inhibitors have been found in amphibian skin. Serine …
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Comparative genomics of bacteria from amphibian skin associated with inhibition of an amphibian fungal pathogen Batrachochytrium dendrobatidis
Chytridiomycosis is a fungal skin disease in amphibians that is primarily caused by Batrachochytrium dendrobatidis (Bd). We analyzed whole genome sequences of 40 bacterial isolates that had been previously cultured from the skin of four amphibian species from Virginia, USA, and tested for their …
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The Structure and Function of Amphibian Skin Bacterial Communities and Their Role in Susceptibility to a Fungal Pathogen
… part of the ongoing loss of global biodiversity, amphibian populations are experiencing declines and extinctions. A primary factor in these declines is the skin disease chytridiomycosis, which is caused by the fungus Batrachochytrium dendrobatidis (Bd). Recent research suggests that the amphibian …
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Measuring and modeling the effects of temperature on the amphibian chytrid fungus and assessing amphibian skin bacterial communities
… conservation efforts. One example of this is the amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd), which causes the disease chytridiomycosis and has been linked to amphibian populations declines worldwide. There have been numerous attempts to mitigate the effects of Bd on amphibians, …
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Bacteriophages in the honey bee gut and amphibian skin microbiomes: investigating the interactions between phages and their bacterial hosts
… bee (Apis mellifera) gut microbiome and the amphibian skin microbiome. My second chapter surveyed publicly available whole genome sequences of common honey bee gut bacterial species for prophages. It revealed that prophage distribution varied by bacterial host, and that the most common …
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Bioactivity evaluation of peptide QUB-1817 from the skin secretion of the Chinese brown frog (Rana chensinensis)
Bioactive peptides from amphibian skin secretions have attracted much attention from researchers because of their profound significance in novel drug development. Many amphibian skin-derived peptides have been proven to possess antimicrobial activity, anticancer activity as well as …
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QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
Amphibian skin secretion is one of the richest sources for antimicrobial peptides (AMPs) which have potent bioactivity and pharmaceutical value for new drug development. In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is …
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