Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"amperometry"”.
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Neurochemical Monitoring in a Humanised Murine Model of Parkinson’s Disease using Amperometry and Microdialysis
The main objective of this thesis was to elucidate an overall neurochemical signature of the progression of patient-specific Parkinson’s disease (PD) through the amperometric monitoring of nitric oxide (NO), oxygen (O2) and hydrogen peroxide (H2O2) coupled with microdialysis sampling. The …
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The Development of Coulostatic Charge Injection Techniques for High Performance Liquid Chromatography Analysis (Electrochemistry, Detection, Amperometry, Hplc)
… pulses are used to mimic controlled potential amperometry. The single pulse technique gives detection limits of 2 x 10('-10) moles Pb(II) at a mercury electrode. Coulostatic pulse amperometry methods were used to quantitate 4 x 10('-11) moles of caffeic acid at a carbon paste electrode.
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Rapidly Scanning Coulostatic Liquid Chromatography/electrochemistry Combined With Conventional Amperometric Detection in a Series Dual-Electrode Cell
… technique of rapidly scanning coulostatic pulse amperometry is combined with conventional fixed-potential amperometry in a series dual-electrode cell to create a novel detector for high performance liquid chromatography. After a preliminary period of electrode evaluation, a flow cell was designed …
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Medida de óxido nítrico por amperometria induzida pela N-saliciloiltriptamina em células endoteliais recém dispersas
… to implement the method of measurement of NO by amperometry at newly scattered en dothelial cells of aorta and evaluate the amount of NO release d by STP, a derivative of benzoyltryptamine s where previous studies have shown tha t it was capable of causing relaxation e ndothelium - dependent in …
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Development and application of electrochemical dithiothreitol (DTT) assay for analysis of particulate matter
… analysis of PM in air samples. Flow injection amperometry was used as the primary electrochemical method. Amperometry was performed using a CH Instruments potentiostat and commercially available DropSens modified carbon screen printed electrodes (SPE's) with a DropSens impinging jet flow cell, …
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Cell biology of settlement and adhesion processes of biofouling algae
… of redox-active substrates was detected using amperometry when settled spores were mechano-stimulated. Secretory events were similar to those seen in bovine chromaffin cells with the presence of foot signals in the recordings implying a role for a ‘fusion pore’ in exocytosis. Using DAF-FM DA …
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Lignin and carbon transformation in roots of maize and mixed perennial biofuel crops
… performance anion exchange chromatography-pulsed amperometry.</p> <p>In general, there were no significant differences in aboveground lignin concentrations of the maize and mixed perennial crops. On the other hand, across all cropping systems, the belowground materials contained more lignin than …
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Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
… reflective fluorescence (TIRF) microscopy and amperometry. A NIR fluorescent sensor NS659 was developed based on the structure of NS510. Several different synthetic routes were attempted before the sensor was successfully prepared. Upon binding to serotonin, the sensor gave a relatively high …
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Novel approaches towards pharmacological enhancement of motivation
… functional imaging measure, in vivo oxygen amperometry, to explore whether a neural correlate of motivated behaviour could be detected in rats. The second section describes the identification and exploration of a novel pharmacological target for treating apathy. By using a progressive ratio …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… examine glutamate regulation in vivo, we used an amperometry coupled to ceramic-based microelectrode arrays (MEAs), which allows for measurement of tonic glutamate levels, potassium-evoked glutamate release, and glutamate clearance from the synapse. P301L tau expression did not affect tonic …
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Optical fibre-based minimally-invasive blood glucose monitoring system.
… that blood glucose monitors (BGMs) based on amperometry are one of the most common technologies to have been developed and used. However, these sensors are problematic. They are invasive in nature and have bio-compatibility issues. Also, these electrochemical sensors are rendered unstable due …
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Polypyrrole Modified with Macrocycles for the Detection of Aqueous Pollutants and Carbon Membranes for the Separation of Gases
… pulse voltammetry (DPV) and constant potential amperometry (CPA) were the techniques employed to evaluate the sensitivity of PPy/sul-bCD and PPy/sul-calix[4] towards the redox states of MV2+, MV+ and MV0 of paraquat. A limit of detection of 1.28 ´ 10-5 mol dm-3 and 3.48 ´ 10-6 mol dm-3 for the …
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Polypyrrole modified with sulfated β-cyclodextrin: characterization and application in the sensing of viologens
… while for methyl viologen constant potential amperometry (CPA) experiments were also performed. These techniques gave a good linear response for the current measured at the polymer surface, as a function of the viologen concentration. Detection limits of 1.00 x 10-4 M for ethyl viologen (DPV), …
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Measurement and Analysis of Calcium-Dependent Exocytosis in Giant Excised Membrane Patches
… (non-SGs) do not contain substances detected by amperometry. Non-SG fusion is reduced by tetanus toxin light chain treatment, however, it is unaffected by N-ethylmaleimide, implying that SNARE cycling is not required for non-SG fusion in excised patches. Although non-SG fusion is ATP-dependent …
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Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… specifically carbon-fiber microelectrode amperometry (CFMA), beyond the study of fundamental cellular biophysics and toward applications investigating the cellular signaling networks in inflammation. From an analytical perspective, the inflammatory response presents several technical …
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The Electrochemical Characterisation of Carbon-based Nanomaterials and their Application in the Detection of Heavy Metal Ions
… this modified electrode using constant potential amperometry and a rotating disk electrode, which is close to the mandatory limits set by the EPA (9.61 × 10-7 M). The detection of Cu(II) was also studied in this thesis. The construction of this sensor involved the modification of an electrode with …
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Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA
… as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. The presence of ATP sensitive channel on the cell membrane permitted the electrical …
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Forebrain Acetylcholine in Action: Dynamic Activities and Modulation on Target Areas
… neurochemical information simultaneously with amperometry. Using this technique on anesthetized rats, I discovered for the first time the tight <italic>in vivo</italic> coupling between phasic ACh release and theta oscillations on fine spatiotemporal scales. In addition, with …
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Single Cell Study of Malaria and Antimalarial Drug Impacts on Platelets and Mast Cells
… cell technique, carbon-fiber microelectrode amperometry (CFMA), platelets and mast cells were studied during malaria infection. Lastly, platelets were studied for their response to two common antimalarial drugs using the same single cell technique. Chapter 1 gives an overview of single cell …
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Biomedical sensor for transcutaneous oxygen measurements using thick film technology
… The devices under investigation were based on amperometry. Gold electrodes were printed on an alumina substrate and covered with a layer of electrolyte gel and then finally, with a membrane. An external silver/silver chloride reference electrode was also employed in this electrochemical cell …
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