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Showing 1 to 4 of 4 for “"aminothiol"”.
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Characterisation of cysteamine prodrugs for the treatment of cystinosis and evaluation of liquid fill technology.
… involves the oral administration of the aminothiol, cysteamine (Cystagon(TM)), but this has an offensive taste and smell, can cause vomiting and its metabolites are excreted from the body via breath (halitosis) and sweat, which can cause poor patient compliance. The main research aim was …
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Development of novel nutrapharmaceuticals combining the anti-oxidant and anti-inflammatory properties of n-3 fatty acids with a nitric oxide donor: a potential new preventative strategy for heart disease.
… qualities of both groups. Synthesis of aliphatic-aminothiol conjugates has been achieved using both acid chloride (N-decanoyl cysteamine (Compound 1), N-decanoyl L-cysteine ethyl ester (compound 3)) and peptide coupling based reactions, and full characterisation has been achieved. The nitration …
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Formulation studies on cysteamine for the treatment of nephropathic cystinosis.
… regular oral and topical administration of the aminothiol, cysteamine (Cystagon TM), which possesses an offensive taste and smell. The oral form frequently causes emesis and should be administered every six hours to be maximally effective. The topical eye-drop treatment requires hourly …
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Detection of Biologically Important Molecules
Anions play important roles in biological systems. The design of anion sensors has been of great interest. The selective detection of a specific anion is particularly challenging. In the first chapter, I describe the synthesis of a TBS-protected fluorescein dye (1.1) and its use for the selective …