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Showing 1 to 2 of 2 for “"aminosteroids"”.
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Synthesis, Design, and Biological Evaluation of Inhibitors and Activators of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP) and Synthetic Studies of Apicularen A and Maoecrystal V
… synthesis, design, and biological evaluation of aminosteroids as inhibitors for the SH2-containing inositol phosphatase 1 (SHIP1). SHIP1, a 145 kDa protein, is involved in regulating the formation of new blood cells. High- throughput screening identified several SHIP inhibitors including …
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CONVENIENT ETHERIFICATION USING TRICHLOROACETIMIDATES AND SYNTHESIS OF AMINOSTEROID SHIP INHIBITORS
… slow the growth of blood cancer cells. Certain aminosteroids show selectivity as SHIP1 inhibitors and therefore may have therapeutic applications. In this study, syntheses of a number of aminosteroid derivatives were performed and these compounds are evaluated for their potential as SHIP1 …