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Showing 1 to 5 of 5 for “"aminolevulinate"”.
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PLP-Dependent α-Oxoamine Synthases: Phylogenetic Analysis, Structural Plasticity, and Structure-Function Studies on 5-Aminolevulinate Synthase
5-Aminolevulinate synthase (ALAS) and 8-amino-7-oxononanoate synthase (AONS) are two of four homodimeric members of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes. The evolutionary relationships among α-oxoamine synthases representing a broad taxonomic and …
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Regulation of human 5-aminolevulinate synthase 2 expression during erythroid differentiation and its role in x-linked sideroblastic anaemia.
… toxic levels of free haem from arising. 5-Aminolevulinate synthase 2 (ALAS2) is the first and rate limiting enzyme in the biosynthesis of haem in erythroid cells. Thus, the regulation of ALAS2 expression is critical for maintaining and controlling haem production during the process of …
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A cancer-targeting liposomal delivery system for photodynamic diagnosis and therapy of cancers in peritoneal cavity
… metastases in the peritoneal cavity. Methyl aminolevulinate (MAL), a protoporphyrin X (PplX) prodrug, has been clinically used for photodynamic therapy of local malignancies such as Basal Cell Carcinoma and Actinic Keratosis. Its application for cancers in the peritoneal cavity, however, has …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… violet growth assays. Furthermore, knockdown of aminolevulinate synthase-1, involved in the first step of the haem synthesis pathway, significantly reduced cell proliferation by approximately 60 %. Interestingly, inhibition of haem synthesis sensitised PC3 cells to ROS. In preparation for …
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Regulation of the chloroplast light harvesting antenna by plastoquinone redox: Modulation of chlorophyll metabolism and thylakoid complex organization
There is currently a great deal of interest in the possibility of modifying photosynthetic parameters to improve photosynthesis, specifically with the aim of increasing crop yields for food and biofuels. Photoinhibition, the reduction of photosynthetic electron transport in the face of excess …