Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"aminoglycoside"”.
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Computer based methods for the prescribing of aminoglycoside antibiotics
The purpose of this study was to produce a computer program which would use clinical information about individual patients to prescribe drug regimes for then. These regimes should ensure that the serum concentration of the drug would remain within a defined therapeutic range during the whole course …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… effective and safe antibiotic options. While aminoglycosides have been effective in treating these life-threatening MDR bacterial infections, clinical treatment with these drugs has been limited due to their high nephrotoxic potential. As a result, aminoglycosides have been conservatively used …
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The genetic location and regulation of aminoglycoside resistance genes in acinetobacter
The genetic basis of aminoglycoside resistance in clinical isolates of Acinetobacter was investigated. The aadB genes cloned from two clinical isolates, strain CHA and strain SUN, were sequenced. Analysis of the sequencing data indicated that both genes were contained on gene cassettes, which had …
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based …
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D-METHIONINE (D-MET) MECHANISMS UNDERLYING OTOPROTECTION FROM NOISE- AND AMINOGLYCOSIDE-INDUCED HEARING LOSS
… has demonstrated otoprotection from noise-, aminoglycoside-, and cisplatin-induced hearing loss in animal studies. As a result, D-met is currently progressing through translational "bench to bedside" research. However, D-met's exact otoprotective mechanisms have not been fully elucidated. …
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The association of IS1133 with an aminoglycoside resistance gene, aacC2a, in Acinetobacter baumannii isolates
Includes bibliographical references (leaves 93-103).
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Application of population pharmacokinetic-pharmacodynamic modelling evaluate and optimise aminoglycoside therapy in patients with cystic fibrosis
… The standard treatment for this infection is an aminoglycoside combined with a β-lactam and patients often receive multiple courses of these antibiotics over many years. Aminoglycosides are narrow therapeutic index drugs where the margin between safety and toxicity is small. Therefore, it is …
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Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
… study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB …
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30S Ribosomal Subunit Assembly is a Target for Inhibition by Aminoglycoside Antibiotics in <em>Escherichia coli</em>.
… also had a second inhibitory effect. I used the aminoglycoside antibiotics paromomycin and neomycin, which bind specifically to the 30S ribosomal subunit. Both antibiotics inhibited the growth rate, viable cell number, and protein synthesis. I used a <sup>3</sup>H-uridine pulse and chase assay to …
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Investigation of the prevalence and role of mobile genetic elements associated with an aminoglycoside resistance gene, aacC2a, in Acinetobacter baumannii
Includes abstract. Includes bibliographical references (leaves 115-141).
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Effectiveness of different medical interventions implemented when a change in hearing status is detected during ototoxicity monitoring
… Tuberculosis (TB) in South Africa (SA) in 2019. Aminoglycosides, which are commonly used anti-tuberculosis drugs in the treatment for RR/MDR-TB patients, are associated with ototoxicity (cochlear or vestibular). Aminoglycoside-induced cochleotoxicity is characterised by permanent, bilateral, …
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Genetic and pharmacokinetics factors associated with susceptibility to kanamycin induced cochleotoxicity in a cohort of patients undergoing MDR/RR-TB treatment
… time of the present study included Kanamycin, an aminoglycoside with a known cochleotoxic effect. Although kanamycin has recently been removed from the WHO MDR/RR-TB regimen, amikacin, another aminoglycoside derived from kanamycin, with similar structure and cochleotoxic side effects, has remained …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
Aminoglycoside antibiotics remain essential for treatment of severe Gram-negative bacterial infections, yet their clinical use is limited by the risk of irreversible sensorineural hearing loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not …
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Antibiotic resistance in the gut microbiota
… to demonstrate the prevalence and diversity of aminoglycoside and β-lactam resistance genes in the adult gut microbiota and highlighted the merits of the approach adopted. Using infant faecal samples, we constructed and screened a second fosmid metagenomic bank for the same families of …
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Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
… a broad-spectrum, bactericidal antibiotic of the aminoglycoside family. It has been shown through extensive evaluation to be effective in the treatment of serious gram- negative bacillary infections (1-5). Gentamicin is one of the few antimicrobial agents available for the treatment of life- …
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Cooperative Electrostatic Polymer-Antibiotic Nanoplexes
… lead to tuberculosis. Current treatments utilize aminoglycoside antibiotics that are polar and positively charged and such drugs do not enter the cells in sufficient concentrations to eradicate the intracellular infections. We have developed core-shell polymeric drug delivery vehicles containing …
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Gentamicin and FM1-43 enter sensory hair cells through mechanosensory transduction channel
… pyridinium dyes and the notoriously ototo.xic aminoglycoside antibiotic drugs, into sensory hair cells: permeation through the transduction channels. Both gentamicin, an aminoglycoside, and FM1-43, a styryl pyridinium dye, rapidly and selectively enter hair cells. The hair cell transduction …
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The Development Of Peptide Ligands To Target H69 Rrna
… </p> <p>The last part of the research focused on aminoglycoside-H69 RNA interactions. ESI MS was used to obtain binding affinities and stoichiometries of 2AP- and A-containing H69 RNAs. The findings revealed that the binding mode had not changed between these two sets of RNAs, which revealed the …
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… Does systemically administered holo-IF prevent aminoglycoside antibiotic induced hearing loss in guinea pigs?</p> <p>Goal: Induce hearing loss in guinea pigs with the aminoglycoside kanamycin and prevent such loss with co-administration of holo-IF.</p>
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