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Showing 1 to 20 of 22 for “"aminoacids"”.
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SMN DEFICIENCY INDUCES NEUROACTIVE AMINOACIDS DYSMETABOLISM: BRIDGING INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL EVIDENCE IN SMA PATIENTS
ABSTRACT Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, driven by homozygous loss of the SMN1 gene and reduced SMN protein. Although disease-modifying therapies such as Nusinersen, Risdiplam, and Onasemnogene abeparvovec have markedly improved survival and motor …
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Chromatographic Separation of Enantiomers of Some Physiologically Active Types of Compounds on Chiral Stationary Phases (Benzodiazepinones, Beta-Lactams, Beta-Aminoacids)
The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΠΑΡΕΝΤΕΡΙΚΗΣ ΧΟΡΗΓΗΣΗΣ ΛΙΠΩΝ, ΑΜΙΝΟΞΕΩΝ ΚΑΙ ΥΔΑΤΑΝΘΡΑΚΩΝ ΣΤΗΝ ΣΥΣΠΑΣΤΙΚΟΤΗΤΑ ΤΗΣ ΧΟΛΗΔΟΧΟΥ ΚΥΣΤΕΩΣ
… THE EFFECT OF INTRAVENOUS ADMINISTRATION OF AMINOACIDS, TRIGLYCERIDES AND GLUCOSE IN THE CONTRACTILITY OF THE GALLBLADDER VOLUME (GBV) AS WELL AS IN THE PLASMA LEVEL OF CHOLECYSTOKININ 90 MIN AFTER THE INITIAL ADMINISTRATION. THE STUDY WAS CARRIED OUT ON 29 INDIVIDUALS. THE CHANGE IN THE GBV …
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Πορείες συνθέσεως ενώσεων με βιολογικό ενδιαφέρον από 2Η-πυραν-3(6Η)-όνες
… starting materials. ii) The synthesis of sugaryl-aminoacids (which may be considered as a new class of compounds of pharmacological interest), by Michael addition of aminoacids to 2H-pyran3(6H)-ones and subsequent reduction of the carbonyl group, as well as the stereochemical aspects of the …
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ΚΙΝΗΤΙΚΗ ΜΕΛΕΤΗ ΚΑΙ ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΑΝΤΙΔΡΑΣΕΩΝ 2,4-ΔΙΝΙΤΡΟΦΘΟΡΟΒΕΝΖΟΛΙΟΥ ΜΕ ΧΡΗΣΗ ΕΚΛΕΚΤΙΚΟΥ ΗΛΕΚΤΡΟΔΙΟΥ ΦΘΟΡΙΟΥΧΩΝ
… SOLUTIONS. STUDY OF THE REACTIONOF DNFB WITH AMINOACIDS AND DERIVATIVES OF PHARMACEUTICAL INTEREST REACTION ORDERS RATE CONSTANTS AND ACTIVATION ENERGY HAVE BEEN CALCULATED. KINETIC-POTENTIOMETRIC METHODS FOR THEIR DETERMINATION ARE PROPOSED. KINETIC STUDY OF THE REACTION OF DNFB WITH AMINES, …
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The Role of Silicates in Interstitial Lung Disease
… The cytoplasmic domain of the SR-AI/II has four aminoacids: Ser25, Ser32, Ser53, Thr34 that can be phosphorylated, and the extracellular region contains a lysine-rich cluster that is required for Acetylated Low density lipoprotein (AcLDL) binding. SR-AI contains a cysteine-rich domain, which is …
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The Role of Silicates in Interstitial Lung Disease
… The cytoplasmic domain of the SR-AI/II has four aminoacids: Ser25, Ser32, Ser53, Thr34 that can be phosphorylated, and the extracellular region contains a lysine-rich cluster that is required for Acetylated Low density lipoprotein (AcLDL) binding. SR-AI contains a cysteine-rich domain, which is …
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Aminoaciduria in childhood
… used to establish the plasma level of certain aminoacids more exactly than was possible by paper chromatography. [From p92, Summary and conclusions] The main diseases investigated were: Lignac-Fanconi disease Cystine-lysinuria Phenylpyruvic oligophrenia Liver cirrhosis and hepatitis …
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ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙ ΠΟΝΤΙΚΟΥ C3HB
… THE RESPONSIBLE AGENT IS MOST LIKELY TRACES OF AMINOACIDS THAT DILUTE THE LABELLEDAMINOACID.
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ΕΠΙΤΑΧΥΝΣΗ ΤΗΣ ΩΡΙΜΑΣΕΩΣ ΤΟΥ ΤΥΡΙΟΥ ΦΕΤΑ
… MAY INCREASE THE AMOUNT OF SMALL PEPTIDES AND AMINOACIDS BY UP TO 400% OF THE NORMAL LEVEL IN 40-DAY OLD CHEESES. ANY INCREASE, THOUGH, OF THESE SUBSTANCES BEYOND 175% OF THE NORMAL, IMPARTED BITTER FLAVOUR TO THE CHEESE. IT WAS ALSO FOUNDTHAT THE ADDITION OF SMALL QUANTITIES OF LIPASE TO THE …
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Oxygen diffusion limitations in pancreatic islet culture and immunoisolation
… a 30-60% positive correction for the presence of aminoacids in Vmax, were used to predict oxygen profiles inside and around islets under perifusion, culture, and immunoisolation conditions. The difference between Michaelis-Menten and zero-order kinetics and the role of the necrosis process in …
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Nanopores for detecting and sensing biological molecules
… of single biological molecules (DNA, proteins, aminoacids, etc.) with solid-state nanopores, atomically-resolved scanning and detection of these molecules remains a significant challenge. In most nanopore-based DNA sequencing and single molecule detection techniques, ionic current blockade and …
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CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS
… The obtained optically pure aminoacids, by means of penicillin acylase, after their reduction to aminoalcohols were then N-acylated with the proper chiral L-methioninesulfone. The diastereoisomeric amides were tested as inhibitors for amidotransferase, an enzyme absent in …
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Elucidating TRPA1 Ion Channel Aberrations in Oesophageal Adenocarcinoma.
… TRPA1 is partially resolved, and the first 445 aminoacids spanning the ARD are missing from the crystallised structure. Through homology modelling, a full-length model of TRPA1 is constructed and the protein’s dynamics are studied by Molecular Dynamics (MD) simulations. MD analyses in coarse- …
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SOTTODOMINI DEL RETICOLO ENDOPLASMATICO IN FISIOLOGIA E PATOLOGIA
… for its transmembrane domain extended of only 5 aminoacids. Previous studies in my laboratory demonstrated that the b5-22 variant inserts initially in the endoplasmic reticulum, but then it distributes disomogenously within the organelle, concentrating into the tubules and into the exit sites. To …
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GENETIC DISSECTION OF PINE1 CONTROLLED STEM ELONGATION AND NEW INSIGHTS INTO LONG DAY FLOWERING IN ORYZA SATIVA
… dominant slender mutants (named slrD) lacks two aminoacids close to the DELLA motif and might be crucial for its degradation, causing SLR1 overaccumulation and dwarf phenotype. Double mutants pine1-gid1, pine1-gid2 and pine1-slrD, even preserving an overall dwarf aspect similarly to gid1, gid2 …
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Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/DNA-RNA/Protein, Where Metal = Platinum(II), Palladium(II)
… a platinum-DNA adduct and their interaction with aminoacids/proteins provide a good first approach for more complex systems.The presence of the nucleobase as a ligand, significantly modifies the biological activity of these complexes by reducing its cytotoxicity and generating a promising …
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
<p>Invasive fungal infections are a major threat to immune-compromised patients. There is a critical need to develop new antifungal agents because of increasing resistance to the common antifungal drugs.</p> <p>In the first part of this dissertation, methods for preparation of novel barbiturate …
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Studien zur Quervernetzung von Milchproteinen und zur Bildung individueller Crosslink-Aminosäuren
Bei der Herstellung und Lagerung von Milch und Milchprodukten kommt es in unterschiedlichem Ausmaß zur Bildung von reversiblen und irreversiblen Proteinquervernetzungen. Dabei verändern sich neben technologischen auch ernährungsphysiologische Eigenschaften des Produktes. Die für die Oligomerisation …
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Nuevas sondas cromo-flurogénicas a partir de derivados organopaladio y compuestos indénicos
Los sensores químicos moleculares, fluorogénicos y cromogénicos han adquirido una gran importancia en el mundo científico, la aplicación de estos sistemas se basa en el desarrollo de sistemas de detección de especies químicas de interés mediante simples cambios de color y/o emisión fluorescente. …
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