Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"amino group"”.
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Development of copper peptide complexes as anti-Inflammatory drugs
… The results that Cu(II) coordinates to one amino group, two deprotonated peptides and one imidazole nitrogen atoms to give a neutral complex. The structures of the complex species were investigated using ultraviolet-visible (Uv-Vis), nuclear magnetic resonance (NMR), electrospray ionisation …
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Studies in the biosynthesis of virginiamycin S₁
Some aspects of the biosynthesis of three amino acid residues in virginiamycin S₁ have been studied in Streptomyces virginiae by the incorporation of amino acid precursors labeled with either radioactive or stable isotopes. L-Lysine-U-¹⁴C was incorporated into both the 4-oxo-L-pipecolic acid and …
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Biochemical Studies of the Purine Analogues, 2-Aminopurine and 2,6 Diaminopurine
<p>An alternating copolymer of deoxy 2,6 diamino purine and thymine (dDAP-T) has been synthesized by substituting 2,6 diamino purine deoxyriboside triphosphate for dATP in a dAT primed synthesis with DNA polymerase. This polymer differs from dAT in having an amino group in the minor groove, and in …
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Development of an electrospary ionization source and vacuum interface for guided ion beam tandem mass spectrometry experiments: structural and energetic effects in the molecular recognition of amino acids by 18-crown-6
… side chains of Lys, Arg, and His and n-terminal amino group have been examined to provide initial estimates of the 18C6 binding affinities of the side chains of AAs. The Bs were extended to natural occurring AAs and further extended to acetylated AAs (AcAA) to determine the binding affinities of …
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Probing Non-Canonical DNA Structures With Anticancer Drugs
… binds to four base pairs with the guanine N2 amino group forming a bifurcated hydrogen bond to a side-by-side Im/Im pair. We then predicted that the free G-N2 amino group in a T:G wobble base pair can form two individual hydrogen bonds to a side-by-side Im/Im pair. Thus an Im/Im pair may be a …
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Surface -enhanced Raman spectroscopic studies of organonitriles on copper colloids
… assisted borohydride reduction of the cyano group to an amino group. SER spectra of the reduction products of the organonitriles in the presence of copper colloids are identical within experimental error. The nu(C≡N) signal was observed when a gold colloid was prepared by borohydride …
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Syntheses of Azido- and Diazido- 10-Methylacridinium Salts.
… good yield from the corresponding nitro- and diaminoacridines. The synthetic scheme involved reduction of the nitro group to an amino function, acetylation of the primary amino group, methylation of the ring nitrogen with subsequent removal of the protecting group and diazotization of the …
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Part I: Self-Assembling Dendrimers Using the Dda-Aad Hydrogen Bonding Motif. Part II: Supramolecular Discotic Liquid Crystals Through Hydrogen Bond Mediated Self-Assembly
… by attachment of a 3,4,5-tris-dodecyloxybenzyl group to the 8-amino group and evaluating the mesomorphic properties of the resulting derivative. Cumulative solution studies by 1H NMR, SEC and DLS indicate the formation of a hydrogen bonded cyclic hexamer in apolar solvents. The studies by …
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Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline
A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the …
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Intra- and intermolecular reactivity of organic diacyl systems
The mechanism or a thermal amino group transfer-fragmentation reaction yielding carboxyamides from mixed phosphoric-carboxylic anhydrides (RO(R¹R²N)P(O)OC(O)R³; R = R¹ = alkyl; R² = H, alkyl, aryl; R³ = alkyl, aryl) was elucidated from structure reactivity studies using a model system, R = R¹ = R² …
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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System
… and a lysine containing a free side chain amino group. Cyclic peptide [(WR)8WK βA] was conjugated through the free side chain amino group of β-alanine with Dox via a glutarate linker to afford [(WR)8WK]bA-Dox conjugate. The conjugate inhibited the cell viability of ovarian adenocarcinoma …
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Chemical synthesis of glycosylated oligoribonucleotides for siRNA development
… reagent. First, a glycan moiety containing an amino group reacted with diethyl squarate to form an activated glycan, which further reacted with an amino modified oligoribonucleotide to form a glycoconjugate under slightly basic conditions. The effect of glycosylation on the stability of RNA …
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Mode of action of antibiotics
… thought of as a ring condensation of two amino acids: alanine and betadimethylcysteine. The various penicillins differ in the substituent acid group coupled to the alanine amino group. Most investigators agree that penicillin produces striking and bizarre changes in the shape and size of …
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Electrochemical detection of chemical warfare agents
… to the literature procedure and modified to 1-amino-n′-ferrocenemethylcarboxylate, 1,n′-H₂N-Fc-COOCH₃ (2) by removing the Boc-group with TFA/Et₃N mixture in dichloromethane. Compound 2 reacted with alkylating agents like MeI, EtI, EtSCH₂CH₂Cl (MA) and (CN)(EtO)₂P(O) (NA) to form MeNH-Fc-COOMe …
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Studies of sequence recognition by the EcoRI restriction/modification system of Escherichia coli
… between the ribose-phosphate backbone and basic amino acids residues on the protein. We have examined DNA-protein interactions involved in the EcoRI recognition process by using defined oligonucleotide duplex substrates with various alterations inside and outside the recognition site. This model …
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Isotopic labelling applied to the infrared spectra of metal complexes
An ir investigation of a series of 2-aminomethylpyridine complexes of first transition metal(II) perchlorates, tetrafluoroborates, halides and thiocyanates is reported. Comparisons with the spectra of related complexes of 2,2'-bipyridine and ethylenediamine together with metal-ion substitution, …
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Hydrolysis of alpha-D-glucosamine-l-phosphate
… investigator concluded that the amino group of ∝-D-Glucosamine-1-phosphate has an appreciable effect on the ease of P-O and C-O cleavage and the position of rate maximum.</p>
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Single label fluorescent derivatization of peptides
… pH that discriminates against $\varepsilon$-amino derivatization in favor of $\alpha$-amino derivatization provided that this group may act as an efficient nucleophile. A kinetic study was performed in order to identify the optimal derivatization buffer pH for $\alpha$-amino group …
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The crystal and molecular structure of thiamine hydroiodide /|nWilliam Edward Lee. -- 260 St. Catharines [Ont.] : Dept. of Chemistry, Brock University,
… c = 20.24 ± 0.02 A, 8 = 120.52 ± 0.07°, space group P2/c, z = 4. A total of 1445 reflections having ,2 > 2o(F2), 26 < 40° were collected on a Picker four-circle diffractometer with MoKa radiation by the 26 scan technique. The structure was solved by the heavy atom method. The iodine and sulphur …
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