Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"amino acid transporters"”.
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Amino Acid Transporters in Arabidopsis Thaliana
Two novel amino acid transporters, LHT1 and ART1, were identified from the Arabidopsis EST cDNA library by complementation. LHT1 is a lysine and histidine transporter, and ART1 is an arginine and aromatic amino acid transporter. ART1 seemed to possess transport activity for IAA and other aromatic …
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Structure-function studies of human SLC36 amino acid transporters
… which are also known as the human Proton coupled Amino acid Transporters (hPATs).This is due to hPATs 1 and 2 having been functionally characterized as proton coupled transporters that bring about a 1:1 symport of H+ and an amino acid across the membrane (with optimum uptake at an extracellular pH …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… a critical need that is met by the excitatory amino acid transporters (EAATs). The presence of at least five isoforms of EAATs raises interesting questions as to potential structural and functional differences among the subtypes. We have investigated possible differences in the ligand binding …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… a critical need that is met by the excitatory amino acid transporters (EAATs). The presence of at least five isoforms of EAATs raises interesting questions as to potential structural and functional differences among the subtypes. We have investigated possible differences in the ligand binding …
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Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei
… mediate the entry of drugs into the cell. Some amino acid transporters fulfil the criteria needed for successful exploitation of nutrient transport systems for drug delivery. The Trypanosoma brucei genomic database was screened to identify the full gene repertoire of amino acid transporters. …
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Molecular mechanisms of thyroid hormone transport: the role of amino acid transporters
… studies indicate that both the aromatic<br/>amino acid System T-type transporter, and the broad scope neutral amino acid<br/>transporter System L are mediators of TH uptake into various cell types.<br/>However cloned amino acid transporters have not been studied to demonstrate<br/>directly …
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Molecular and Physiological Analysis of Putative Amino Acid Transporters in Arabidopsis Thaliana
Amino acids are the currency of nitrogen exchange in plants and their physiological and molecular analysis is essential. The objective of this thesis was to identify and analyze plant amino acid transporters using the model plant Arabidopsis thaliana. A valine resistant T-DNA insertion mutant was …
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Understanding the role of host amino acid transporters in nutrient acquisition by oomycete pathogens
… from the host in an organic form; possibly amino acids. Using a reverse genetic approach, I was able to identify two host amino acid transporters that are up-regulated during Hpa infection: AAP3 and AAP6. Both of these transporters are localized in the vasculature of the plant, AAP3 mostly …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT subtype-specific inhibitors demonstrated that in both WT and PrP KO astrocytes, …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT subtype-specific inhibitors demonstrated that in both WT and PrP KO astrocytes, …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… effort by a variety of cell membrane spanning amino acid transporters and amino acid converting enzymes, glutaminase and glutamine synthetase. This work details the design and synthesis of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… effort by a variety of cell membrane spanning amino acid transporters and amino acid converting enzymes, glutaminase and glutamine synthetase. This work details the design and synthesis of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of …
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Regulatory Balance Between the Peptide Trasporter, Pept1, and Amino Acid Transporter Gene Expression in the Enterocyte
Amino acids are assimilated by membrane-associated transporters into and out of enterocytes either in their free form or in the form of peptides. The peptide transporter, PepT1, is thought to be the major facilitator of peptide transport in the enterocyte. It is unknown if the peptide transporters …
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Characterization of the amino acid transporter AAP1 in Arabidopsis thaliana
Amino acids are essential molecules in plant metabolism. Amino acids carry reduced nitrogen while serving as precursors for protein synthesis and secondary metabolites. Translocation of amino acids in the cell is mediated by amino acid transporters. While about 100 transporters have been …
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NAT2/AAP1 as a Prototypical Example of the AAP Amino Acid Transporter Gene Family: From Protein Topology to Regulation of Gene Expression
… evidence connecting nitrate assimilation and amino acid transport. This observation supports the notion that NAT2 may be involved in phloem loading of newly synthesized amino acids in leaves. In addition, carbohydrate is able to enhance NAT2 expression in dark-adapted plants, suggesting the …
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Lysosomal nutrients and the mTORC1 pathway
… of mTORC1 localize to the lysosomal surface, and amino acids generated by lysosomes regulate mTORC1 by promoting its translocation there, a key step in its activation. Activation of mTORC1 by the amino acid arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in …
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Structure and function of glutamate transporters
… with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in …
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Structure and function of glutamate transporters
… with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we …
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