Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"amino acid transport"”.
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Studies of Mammary Amino Acid Transport
… to study several different aspects of mammary amino acid transport. The experimental animals utilized were cow and rat. The major conclusions include the following: (1) Mammary tissue was shown to have relatively high (gamma)-glutamyl transpeptidase activity, and activity increased at the onset …
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The effect of sugars on amino-acid transport
At the turn of this century the form in which ingested protein was absorbed from the intestine was unknown. Voit had postulated in 1867 that protein was absorbed as such, and passed through the blood to the tissues, where it was oatabolised without becoming part of the "living protoplasm". This …
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Osmoregulation of system A amino acid transport in cultured mammalian cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Role of Amino Acid Transport in the Regulation of mTORC1 by Metformin
… signalling by inhibiting its activation by amino acids in an AMPK-independent manner. Furthermore, we present evidence to suggest that this occurs through a reversible mechanism ‘upstream’ of the amino acid sensor involving inhibition of hepatic uptake of leucine, a potent stimulator of …
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Regulation of amino acid transport across the lysosomal surface by the mTORC1 pathway
… which integrates various inputs such as amino acids, growth factor signaling and energy levels. Amino acids promote the localization of mTORC1 to the lysosomal surface, where it can then be activated in response to growth factor availability. While the Rag GTPases mediate the recruitment …
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Evaluation of amino acid transport and protein metabolism in the mammary gland of dairy cattle
… of milk protein production regulation and AA transport is important for successfully formulating diets for AA and improving N efficiency. The objectives were to study protein synthesis regulation and AA transport using in vitro and in vivo models. In the first experiment, the objective was to …
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Demonstration of peptide and free amino acid absorption by sheep forestomach epithelium using parabiotic chambers and identification of H⁺/peptide and free amino acid transport proteins in sheep omasal epithelium and b<sup>o,+</sup> amino acid transport proteins in pig jejunal epithelium by expression of mRNA in Xenopus laevis oocytes
… complementary to the cloned human kidney b⁰‘⁺ transporter. Oocytes were injected with RNA isolated from omasal epithelial tissue of sheep (average BW = 67.5 kg) to identify potential peptide and amino acid transport proteins. Injection of specific RNA fractions induced greater rates of …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… effort by a variety of cell membrane spanning amino acid transporters and amino acid converting enzymes, glutaminase and glutamine synthetase. This work details the design and synthesis of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… effort by a variety of cell membrane spanning amino acid transporters and amino acid converting enzymes, glutaminase and glutamine synthetase. This work details the design and synthesis of amino acid analogs, based off of an L-aspartate or L-proline scaffold, to be evaluated as inhibitors of …
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Sideroflexins enable mitochondrial transport of polar neutral amino acids
… of metabolism necessitates regulated transport of metabolites across the inner mitochondrial membrane. While many proteins enabling mitochondrial membrane transport of metabolites are known, how some metabolites are transported is not known, and several mitochondrial amino acid …
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The Physiological Response of Staphylococcus Aureus Mf-31 to Conditions of Reduced Water Activity
… of reduced a(,w) on the intracellular free amino acid pools, amino acid transport, glutamine synthesis, and proline oxidation in S. aureus. In addition, the effect of a(,w) on the intracellular free amino acid pools of eight other bacterial species was examined. Further, the water binding …
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Amino Acid Transporters in Arabidopsis Thaliana
Two novel amino acid transporters, LHT1 and ART1, were identified from the Arabidopsis EST cDNA library by complementation. LHT1 is a lysine and histidine transporter, and ART1 is an arginine and aromatic amino acid transporter. ART1 seemed to possess transport activity for IAA and other aromatic …
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NAT2/AAP1 as a Prototypical Example of the AAP Amino Acid Transporter Gene Family: From Protein Topology to Regulation of Gene Expression
… evidence connecting nitrate assimilation and amino acid transport. This observation supports the notion that NAT2 may be involved in phloem loading of newly synthesized amino acids in leaves. In addition, carbohydrate is able to enhance NAT2 expression in dark-adapted plants, suggesting the …
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The regulation of CD8+ T cells by nutrient availability
… function of autophagy as CD8 T cells encounter amino acid deprived conditions. The study also examined the role of the AMP dependent kinase in CD8+ T cell responses to metabolic stress. To study autophagy a novel fluorescent autophagy reporter mouse model was used that allowed for quantitative …
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Understanding the physiological role of the small RNA RydC
… shown to stabilize cfa (cyclopropane fatty acid synthase) mRNA, resulting in higher levels of cyclopropane fatty acids in the cell membrane. Here, we show that additional sRNAs, ArrS and CpxQ, also directly regulate cfa post-transcriptionally. RydC and ArrS act through masking an RNase E …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… were treated with the short-chain fatty acid salt sodium butyrate (NaB), previously reported to increase permeability without harm. High NaB concentrations (50–125 mM) reduced transepithelial electrical resistance (TEER) and increased paracellular permeability of Caco-2 monolayers in a …
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Preserving spore dormancy
… needed for their catabolism are absent, these amino acids accumulate and trigger premature germination. Alanine depletion is not simply general nutrient consumption, since amino acids are removed with different efficiencies. Other alanine-germinating Bacillus species also deplete alanine …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… of this study was the investigation of several transport systems expressed at the BBB. The identification and functional characterization of such transport systems is essential to provide a basis for strategies to regulate drug disposition into the brain. Immortalized rat brain endothelial cells …
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Characterizing the role in amino acid sensing and signaling of Amino Acid Permease 1 in Arabidopsis
Amino acids are necessary for protein synthesis and specialized metabolism in plants. Yet very little is known about how plants sense and regulate when and where to allocate amino acids to meet the demand for nitrogen in growing tissues. In particular, while characterized in yeast and mammals, no …
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