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Showing 1 to 5 of 5 for “"amino acid homeostasis"”.
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GCN2 eIF2 Kinase Promotes Prostate Cancer by Maintaining Amino Acid Homeostasis
… of the ISR in PCa and is crucial to maintaining amino acid (AA) homeostasis. GCN2 is activated in PCa due to AA limitation, resulting in increased expression of key AA transporters which providing nutrient import to fuel protein synthesis and metabolism that drive prostate tumor cell …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
Amino acid homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support …
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A Study of Cellular Amino Acid Homeostasis Identifies Novel Targets, Inhibitors and Combination Therapies in Cancer
Amino acid homeostasis is maintained by a combination of transmembrane transport processes, metabolic pathways, protein synthesis and turnover, and signalling systems to furnish cells, tissues, organs, and organisms with optimal levels of these nutrients. Understanding how these elements support …
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Characterization of the Arabidopsis glutamine dumper1 mutant reveals connections between amino acid homeostasis and plant stress responses
Amino acids constitute the major organic form of transported nitrogen in plants, elements for protein synthesis, and precursors of many plant secondary metabolites, such as lignin, hormones, and flavonoids. Furthermore, amino acid metabolism lies at the crossroad of carbon and nitrogen metabolism. …
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Characterization of the amino acid transporter AAP1 in Arabidopsis thaliana
Amino acids are essential molecules in plant metabolism. Amino acids carry reduced nitrogen while serving as precursors for protein synthesis and secondary metabolites. Translocation of amino acids in the cell is mediated by amino acid transporters. While about 100 transporters have been …