Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"amine synthesis"”.
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Charge-Transfer Complexes for Amine Synthesis
… reaction was developed, combining secondary amines, cyclopropyl carboxaldehydes and alkenes, to generate cyclopentyl methylamines. To initiate the fragmentation step, single-electron reduction of alkyliminium ions to α-amino radicals was achieved, using an aromatic thiol and visible light …
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The photoredox-catalysed generation and reaction of alkyl α-amino radicals for α-tertiary amine synthesis
… thesis comprises three projects focused on the synthesis of α-trialkyl-α-tertiary amines, exploiting photo-reductively generated alkyl α-amino radicals as intermediates. The first project describes the development of a multicomponent method for the photoredox-mediated synthesis of α-trialkyl …
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The Use of High-Throughput Experimentation to Accelerate the Development of Methods for Complex Amine Synthesis
… synthetic methods to access is ⍺-branched amines. The ability of the α-branched amine motifs to modulate key biological interactions and regulate the physicochemical properties of molecules has led them to become ubiquitous structural features in pharmaceutical agents. Despite many …
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A novel photocatalytic strategy for complex aliphatic amine synthesis and the total synthesis of alkaloids (−) FR901483 and (+)-TAN1251C
Owing to their unique properties, the synthesis and functionalization of aliphatic amines plays a central role in the field of visible light photoredox chemistry. In this thesis, the development of a novel, visible light mediated process for the synthesis of complex aliphatic amines is described. …
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Quinone-Catalyzed Amine α-C–H and α-C–C Functionalization
Amines are extremely useful compounds with diverse applications in multiple disciplines. For this reason, a myriad of synthetic methods has been developed for the preparation of amine compounds. Despite this, the majority of well-established methodology for amine synthesis relies on the …
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Machine-assisted synthesis and development in pharmaceutical industry
Machine-assisted synthesis and development in pharmaceutical industry Perman Jorayev Process development of novel chemical transformations is often a laborious and complex task. This is mostly due to the difficulties in identifying the underlying reaction mechanism(s), selection of chemical …
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Modular Approaches for the Synthesis of α-Azinyl Amines and Related Scaffolds
… three projects all with a central focus on the synthesis of α-alkyl 2-azinyl amines and related scaffolds in a modular fashion. The first project describes the development of an operationally straightforward and general multicomponent carbonyl azinylative amination process. This protocol, which …
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HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… science, biological processes, and organic synthesis. As synthetic intermediates, these scaffolds can be used as precursors to valuable piperidine derivatives and have recently emerged as important cross coupling handles for metal-catalyzed processes. Unfortunately, current methods to access …
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Radical methods for the synthesis of aliphatic amines
The aliphatic amine motif is a ubiquitous and uniquely important functional group in pharmaceutical agents and the development of ever more efficient synthetic methods for their synthesis is a continuous challenge. This thesis details the development of three new radical reactions for the synthesis …
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New Pd and Cu-based catalysts for carbon-heteroatom bond formation
… bonds directed towards aryl sulfonamide synthesis. The second part of the thesis describes the recent development in the copper(!) hydride mediated formation of carbon-nitrogen bonds via hydroamination of olefins. Part I. Chapter 1. Palladium-Catalyzed Chlorosulfonylation of Arylboronic …
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Visible-light-mediated synthetic strategies for the synthesis of α-tertiary amine derivatives
The α-tertiary amine—a nitrogen atom with an α-carbon bearing three C–C bonds—is a motif that is widely prevalent in pharmaceutical materials and natural products. As a result of the fully substituted α-centre, compounds bearing this fragment have a high degree of structural complexity. This …