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Showing 1 to 20 of 159 for “"amination"”.
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Hydro-amination of low alcohols
… acids, glycerol and some antibiotics; Hydroamination of low alcohols (C2-C4) over Co/Si02 catalysts yielding amines, has been selected as an option to add value to these materials. This process involves reaction of alcohol with ammonia at temperatures ranging from 150 to 210°C and pressures …
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Manganese-catalyzed intermolecular benzylic C–H amination
… molecule. While selective intramolecular C—H amination reactions are known, intermolecular C—H amination reactions with high reactivity and selectivity are scarce. Achieving high levels of reactivity while maintaining excellent site-selectivity and functional group tolerance remains an …
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New methodology for the organocatalysed α-Amination reaction
… by List and Jørgensen, the organocatalysed α-amination reaction has become a key method for asymmetric heteroatom functionalisation of carbonyl compounds. Herein we report the first application of this methodology to acetals, with the ultimate goal of applying the methodology to the asymmetric …
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The Electrophilic Amination of Organolithium Compounds With Methyllithium-Methoxylamines
… a stepwise or concerted mechanism in these amination reactions using N-methyl-O-(2-bromo)benzylhydroxylamine and N-methyl-d(,1)-O-(2-bromo-(alpha),(alpha)-dideutero)benzylhydroxylamine to provide N-methyl-2-aminobenzyl alcohol, isolated as its N,O-diacetyl derivative, in 13% yield. The …
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Methanol amination over hydrothermally treated zeolites RHO and Modernite
… as being used on their own. The acid catalysed amination of methanol generally yields a thermodynamically controlled product distribution. The equilibrium distribution for mono-, di-, and trimethylamine (MMA, DMA, and TMA), at 325°C and a molar methanol to ammonia ratio of 1, is 17, 21, and 62 …
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New Functionalized Grignard Reagents and their Applications in Amination Reactions
Im Rahmen der Dissertation „Funktionalisierte Grignard-Reagenzien und ihre Anwendung in Aminierungsreaktionen wurden insbesondere nitrofunktionalisierte Aromaten und Ihre Reaktionen mit Magnesiumorganylen untersucht. Im ersten Teil der Dissertation wurde die Kompatibilität der Nitrofunktionalität …
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New frontiers in allylic C––H amination via palladium/sulfoxideoxazoline catalysis
… methods for Pd(II)-catalyzed allylic C––H amination exists. However, all these reactions proceed via near ligandless conditions (e.g. reversibly coordinating sulfoxide ligands) and require benzoquinone oxidant to coordinate to Pd metal to promote the functionalization step (known as “serial …
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Defining the substrate scope of DNAzyme catalysis for reductive amination with aliphatic amines
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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Late-stage C(sp3)–H hydroxylation, amination, and methylation in nitrogen-containing molecules
… strategy to enable late-stage benzylic amination in amines, pyridines, imide, and benzimidazole. Although preparative benzylic amination is achievable with rhodium catalysis, its functionalization of basic amines either only occur alpha to nitrogen and on nitrogen, or does not occur at …
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New horizons of aliphatic C—H amination and hydroxylation reactions with manganese catalysis
… on developing novel manganese catalysts for C—H amination and C—H hydroxylation reactions with unprecedented amalgamation of high reactivity with strong C—H bonds (2º and even 1º) while maintaining high chemoselectivity for aromatic -functionalities. These new catalysts afford opportunities to …
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The Exploration of a Strategy for Regioselective Arene Amination Utilising Non-Covalent Interactions
… cations resulted in an ortho-selective radical amination, allowing access to ortho-phenylenediamine products. This work was subsequently expanded upon to include arenesulfonates and arenecarboxylates as substrates for ion pair-directed ortho-selective amination. In these cases, the reaction …
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Studies on Organophosphorus Catalyzed C(SP³)–H Amination for the Synthesis of Benzimidazoles
A PIII/PV=O-catalyzed C(sp³)–H amination has been realized for (dihydro)benzimidazole synthesis. This work reports: (1) optimization of organophosphorus-catalyzed C(sp³)–H functionalization; (2) scope studies to benzimidazoles by in situ oxidation of the corresponding dihydrobenzimidazole; and (3) …
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Development of palladium catalyzed intramolecular allylic C―H amination and oxidation towards pharmacological motifs
… Pd(II)/bis-sulfoxide-catalyzed allylic C—H amination reaction en route to syn-1,3-amino alcohol motifs is first demonstrated. This reactivity is achieved under mild conditions through the use of electron-deficient N-nosyl carbamate nucleophiles. These nucleophiles are thought to promote …
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METAL-FREE SELECTIVE SP3 C-H IMINATION AND COVALENT POSTSYNTHETIC MODIFICATION OF POLYSTYRENE BY DIRECT C-H AMINATION
… demand for methods enabling direct alkane C–H amination. Alkylamines are commonly found as natural products and bioactive compounds, and amino functionalization can improve the properties of commodity polymers. Transition-metal-catalyzed C–H amination has emerged as a powerful tool for C–N bond …
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Investigations of Catalysts Which Utilise Non-Covalent Interactions to Control Enantioselectivity in Rhodium-Catalysed Amination of C(sp3)–H Bonds
… into enantioselective benzylic C(sp3)–H amination via bis-sulfonated rhodium(II) dimers ion-paired with N-quaternised Cinchona alkaloids are described herein. Design and initial synthesis of these novel catalysts was performed prior by Dr. Alex Fanourakis, and their application towards …
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I. Palladium-catalyzed anti-Markovnikov oxidative amination of olefins II. Catalytic deracemization of axially chiral diols III. Three component carboamination of electron deficient alkenes
… a palladium-catalyzed anti-Markovnikov oxidative amination of unactivated alkenes. This transformation allows for the generation of primary C–N bonds by coupling the terminus of a C–C double bond with an acidic nitrogen nucleophile such as phthalimide. As the terminal oxidant is molecular oxygen, …
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Hemiaminals : a new chemotype for organocatalysis
Jorgensen and List introduced enantioselective α-amination of an aldehyde with an azodicarboxylate as the electrophile using L -proline enamine catalysis in 2002. Following borohydride reduction, the α-hydrazino alcohol was obtained in high yield (93-99%) and enantioselectivity (86-97%). …
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C(sp3)-H aminations under first row transition metal catalysis
… to introduce nitrogen (e.g. Mannich, reductive amination) often rely on pre-existing functionality and require additional transformations such as oxidation state changes and/or protecting group maniuplations. C—H amination represents a powerful alternative synthetic strategy. This approach …
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Charge-Transfer Complexes for Amine Synthesis
… aldehydes, by development of a radical reductive amination, using thiol as the single-electron reductant and hydrogen atom source. Subsequently, the chemoselective reductive amination of secondary amines over primary amines was attempted. Preliminary studies on a di-amine drug indicated that the …
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