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Showing 1 to 9 of 9 for “"amide Hydrolysis"”.
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Amide hydrolysis by catalytic antibodies
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles
… conditions and the proposed mechanism was amide hydrolysis. Typically, amide groups are stable and hydrolyze slowly in absence of enzyme. Different models mimicking PGAAs were synthesized to study the fast hydrolysis. Amide groups showed asymmetric hydrolysis. Different hydrolysis behaviors …
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Modifikace peptidového substrátu pro pappalysiny zavedením pseudopeptidu do štěpeného místa
… mimics the tetrahedral transition state (TS) of amide hydrolysis. By inserting the block into the cleavage site of the peptide, a potential inhibitor of pappalysins could be prepared, which could be used as a medical drug for several diseases related to the activity of IGFs. The first part of the …
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INHIBITION OF THE SERINE PROTEASE CHYMOTRYPSIN BY A SILANEDIOL PEPTIDE MIMIC: ASYMMETRIC SYNTHESIS AND INHIBITION STUDIES
… analogs of the tetrahedral intermediate of amide hydrolysis and have shown outstanding inhibition of metallo and aspartic proteases. This research describes the synthesis and inhibition of the serine protease α- chymotrypsin by silanediol structures and the development of an efficient method …
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Nucleobase-modified deoxyribozymes for amide and peptide hydrolysis
… experiments for DNA-catalyzed ester and amide bond hydrolysis employed an additional capture step to avoid identifying deoxyribozymes for phosphodiester cleavage, leading to the identification of deoxyribozymes for ester hydrolysis and aromatic amide hydrolysis. However, no deoxyribozymes …
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Synthesis of enantio-pure amides by reversal of the Geobacillus pallidus RAPc8 amidase hydrolysis reaction in non-aqueous media
Amidases are hydrolytic enzymes that catalyze the hydrolysis of amides to their corresponding carboxylic acids and ammonia. Amidases are ubiquitous in nature, and they have been isolated from a wide range of microorganisms, the most common source being bacteria. Amidases are recognized as potential …
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Catalytic antibodies for amide cleavage and prodrug activation
… thesis describes a novel approach to generate amide cleaving antibodies. Two haptens, O1 and O2, were designed and synthesized to create a hydrophobic pocket for an auxiliary nucleophile as well as elicit complementary basic/acidic side chain residues in the antibody combining binding site. The …
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The crystal structure of an aliphatic amidase from Geobacillus pallidus RAPc8
… enzymes that catalyze the conversion of amides to corresponding carboxylic acids and ammonia. These enzymes are of great interest in synthetic industries where they are used for mass production of acidic products. Aliphatic amidase from Geobacillus pallidus RAPcS (RAPcS amidase), which …
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Poly(glycoamidoamine)s: Understanding their Structure and Structure-Bioactivity Relationships
… is dedicated towards understanding the hydrolysis pattern of plasmid DNA (pDNA) delivery vehicles comprised of poly(glycoamidoamine)s (PGAAs) under physiological conditions and effects of subtle changes in the chemical structure of the PGAAs on its biological performance. The unusual …