Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"amantadine"”.
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Molecular Simulation For Neurodegenerative Diseases: From Modelling Alpha-Synuclein In Aqueous Solutions To Drug Delivery Systems
… steps of alpha-synuclein aggregation as well as amantadine for drug delivery systems. The aggregation and fibrillation of alpha-synuclein, a brain protein of 140 residues, has been linked to several neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. Using molecular …
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Investigating the role of neuroinflammation in a mouse model of L-Dopa induced dyskinesia and exploring the anti-dyskinetic potential of a cannabinoid receptor agonist
… or if a known anti-dyskinetic treatment (amantadine) is capable of reducing neuroinflammation. To achieve these aims we utilized the 6-hydroxydopamine (6-OHDA) mouse model that recapitulated the cardinal behavioral and pathological features of both PD and LID. We first conducted a time …
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Structure and dynamics of full-length M2 protein of influenza A virus from solid-state NMR
… and the interaction of the anti-viral drug amantadine with M2 in the presence of the C-terminus. Using uniformly ¹³C, ¹⁵N-labeled M2FL, our water-selected 2D ¹³C-¹³C correlation experiment indicated that N- and C- termini are on the surface of the lipid bilayer moreover combining with …
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Structure and dynamics of influenza M2 proton channels from solid-state NMR
… is targeted by the FDA-approved antiviral drugs amantadine and rimantadine to inhibit viral replication. Proton conduction by M2's TM is mediated by a His-xxx-Trp motif conserved in the otherwise disparate M2 from influenza A (AM2) and influenza B (BM2) strains.
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
… including dyskinesia which can be treated with amantadine, an N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led to the hypothesis that NO, produced by …
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The function of the hepatitis C virus p7 protein
… was blocked by the viroporin inhibitors amantadine, rimantadine and hexamethylene amiloride. Fluorescence microscopy using pH indicators in live cells showed that both HCV infection and expression of p7 from replicon RNAs reduced the number of highly acidic (pH<5) vesicles and increased …
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Chlorellavirus-Proteine: I. Die Hüllprotein-Genfamilie II. Ein primitiver Kaliumkanal
… laevis oocytes, which is inhibited by Ba2+ and amantadine, but not Cs+. Virus replication is inhibited in the same fashion, which indicates a role of Kcv in the viral life cycle. Thus, Kcv is the first potassium channel which is encoded by a virus. No proteins with structural analogy to Kcv have …
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Virus elimination from Actinidia germplasm
… The effects of anti-viral compounds (acyclovir, amantadine hydrochloride, 5-azacytidine, oseltamivir, ribavirin, 2-thiouracil, and vidarabine) against AMV, ASGV, AVX, CLBV-a, and CMV in N. occidentalis shoot tip cultures cultures was determined. Only ribavirin (20mg/L) and ribavirin (10mg/L) …
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Viruslastorientierte Interferon-a-2a-Therapie der chronischen Hepatitis-C-Infektion in Kombination mit Ribavirin und Amantadin
Bei Patienten mit einem Breakthrough oder Relapse nach einer Interferon-Monotherapie oder der Standard-Kombinationstherapie mit Interferon und Ribavirin erreichte eine Re-Therapie mit einer Dreifachkombination aus Interferon, Ribavirin und Amantadin eine hohe Rate an anhaltendem virologischen …
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Properties of Conductance and Inhibition of Proton Channels: M2 from Influenza A Virus and Fo from Escherichia coli ATP Synthase
<p>Proton channels are essential for many of the processes of life. The influenza A viral protein M2 is responsible for sensing the conditions necessary for viral RNA release. The proton-translocating FoF1 ATPase (ATP synthase) uses a proton gradient to drive adenosine triphosphate (ATP) synthesis. …
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Characterization of the Zona Incerta
Parkinson's Disease affects more than 1 million people in the United States with 60,000 new cases being diagnosed each year. Currently, there is no cure for Parkinson's Disease, but there are several treatment options available. Currently the most popular surgical option is Deep Brain Stimulation. …