Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"amacrine"”.
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Receptor-mediated calcium entry in retinal amacrine cells
… and TRPC4. TRPC1 expression was observed in amacrine cells and their process in the chicken retina. TRPC4 expression was much more widespread with some degree of labeling found in all layers of the retina, and was shown to be expressed in Müller glial cells. Thus, the distributions of these …
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Direct Inputs to off Α and G9 Ganglion Cells From Aii Amacrine Cells In Rabbit Retina
In the mammalian retina, AII amacrine cells are essential in the rod pathway for dark-adapted vision. But they also have a “day job”, to provide inhibitory inputs to certain OFF ganglion cells in photopic conditions. This is known as crossover inhibition. Physiological evidence from several …
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A connectomic analysis of the directional selectivity circuit in the mouse retina
… and more recently confirmed in the starburst amacrine cell. Upstream retinal bipolar cells, however, have been shown to lac, indicating that the mechanism that gives rise to DS lies in the inner plexiform layer, where the axons of bipolar cells costratify with amacrine and ganglion cells. We …
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Calcium-dependent mechanisms in the chicken retina
Multiple classes of retinal amacrine cells use L-type Ca2+ channels to mediate synaptic transmission. I have used whole cell voltage clamp recordings from primary cultures of amacrine cells to investigate the regulation of these channels. In this study, I show that inhibiting mitochondrial calcium …
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Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
… retinal neurons, including the Cx36-coupled AII amacrine cell in the primary rod circuit, is a hallmark of retinal luminance adaptation. However, very little is known about the mechanisms regulating dynamic modulation of Cx36-mediated coupling. The primary goal of this work was to understand how …
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Expression of microbial rhodopsins in retinal neurons with subcellular targeting motifs: for the study of the structure/function of aii amacrine cells and for vision restoration
… dissertation reports in the axonless spiking AII amacrine cell of the mammalian retina a dendritic process sharing organizational and functional similarities with the axon initial segment, the typical site of action potential initiation. This process was revealed through viral-mediated expression …
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… <em>OTX2ECR2</em> in both rod photorceptors and amacrine cells. Since in the past there have been studies of retinal progenitor cells that are OLIG2+ that give rise to both rod photoreceptors and amacrine cells, we decided to test if these same cells would have a history of <em>OTX2ECR2</em>. In …
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… i), we found that R7BP is expressed in starburst amacrine cells (SAC) and retinal ganglion cells (RGC). R7BP regulates mesopic RGC light responses and glutamatergic wave burst duration in mature and developing retina, respectively. In part ii), we found that R7PB is expressed in the dLGN. R7BP …
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Investigating Cellular and Molecular Mechanisms of Neuronal Layering in Self-Organising Aggregates of Zebrafish Retinal Cells
… distinct layers: Retinal Ganglion Cell (RGC), Amacrine Cell (AC), Bipolar Cell (BP), Horizontal Cell (HC) and Photoreceptor cell (PR) layers. This remarkable organisation is evolutionarily conserved in vertebrates, yet little is known about the mechanisms by which these cells form the correct …
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Cellular and Molecular Mechanisms of Retinal Neuron Spatial Patterning
… of interneurons, the OFF and ON starbursts amacrine cells (SACs), which require the cell-surface receptor MEGF10 to establish their mosaics. We find that SACs in Megf10 mutants still make lateral movements in the plane of the retina, but fail to recognize their proximity to homotypic …
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Dynamic changes in the localization of synapse associated proteins during development and differentiation of the mammalian retina
… is at relatively high levels in cholinergic amacrine cells during their differentiation, but not at maturity. This transient expression of high levels of SNAP-25 may contribute to the functional role these cells play in propagation of spontaneous retinal activity. Spatial and temporal …
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Characterization Of Adult Zebrafish Retinal Regeneration Following Two Different Damage Models
… Additionally, Shh is required for proper amacrine and ganglion cell differentiation following Ouabain damage. In summary, these experiments will elucidate the molecular requirements at critical stages in retinal regeneration in the zebrafish and reveal targets for advances in sight-saving …
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Characterization of Retinal Defects in Engrailed-2 Knockout (En2-/-) Mice, a Model for Autism Spectrum Disorders (ASD)
… a significantly increased number of Calbindin+ amacrine/ganglion cells. The number of Brn-3a (Brn-3a+) positive ganglion cells displayed no difference with respect to wild-type littermates. In addition, En2-/- adult mice showed a significantly reduced expression of the rod photoreceptor marker …
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Metabolic and functional approaches to investigate the effects of cytokines on the physiology of in-vitro and in-vivo models of diabetic retinopathy
… resulted in increased cation permeation into amacrine and ganglion cells in DR conditions, suggesting that these cells are specifically involved in the progress of DR. Finally, to confirm the findings from the in-vitro model and assess DR pathogenesis, an in-vivo mouse DR model incorporating …
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Cloning and functional characterization of novel genes expressed preferentially in the human retina
… photoreceptors, bipolar cells, ganglion cells, amacrine cells, horizontal cells and Müller glia. In response to light, a coordinated series of molecular events, the so-called phototransduction cascade, is triggered in photoreceptor cells and the signals from the photoreceptors are further …