Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alveolar stem cells"”.
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An organoid platform to study alveolar stem cells in lung generation and cancer
… initiation from normal pulmonary epithelial cells and progression into a malignant state. The development of organoid technology has revolutionized the way we model cancer and a vast number of other biological phenomena.
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Cellular Ensembles in Alveolar Homeostasis and Repair
… damages. In adult mammalian lungs, epithelial cells are generally quiescent but can respond rapidly to repair damaged tissues. Evidence from experimental injury models in rodents and human clinical samples has led to the identification of these regenerative cells, as well as pathological …
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
… adult distal lung parenchyma is maintained by alveolar type 2 (hAT2) cells that have the ability to self-renew and differentiate into alveolar type 1 (hAT1) cells, a critical cell type involved in gas-exchange. Cellular damage within the alveoli can lead to severe lung dysfunction, and major …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, little progress has been made in understanding the precise sequence of events that transform single AT2 cells into …