Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alternatives to animal testing"”.
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Development of an analytical method to derive hydrophobicity parameters for use as descriptors for the prediction of the environmental and human health risk of chemicals
There is a requirement to assess the safety of chemicals to both 'man' and the environment. Traditionally this was determined through the use of animal testing. However, there is an increased need to develop alternatives to animal testing for the determination of toxicity due to ethical and …
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Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
The assessment of teratogenic effects of chemicals is generally performed using in vivo teratogenicity assays e.g., in rats or rabbits. Following the 3R principles, the development of alternative methods is encouraged to reduce the number of animal tests. From this perspective, we have developed an …
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Development of a computational consensus model for the in silico prediction of the skin sensitising potential of organic chemicals in the context of REACH
… (Typ 4 Hautallergie) nimmt in der Toxizitätsbewertung einen wichtigen Stellenwert ein, was u.a. daran zu sehen ist, dass sie unter dem europäischen Chemikaliengesetz REACH schon sehr früh, d.h. ab einer Jahrestonne, abgeprüft werden soll. Die Dissertation untersucht, ob die derzeit …
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Analysis of DNA damage and repair responses in cerium exposed cells and hepatocyte spheroids
… and industrial chemicals, have long been known to impact public health and safety by contributing to the risk of developing cancer. One key concern is a chemical's potential to induce DNA damage, as damage can lead to the formation of mutations that drive cancer. While cancer can take years to …