Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"alternatively-activated macrophages"”.
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Transcriptomic phenotyping of the macrophage response to filarial nematode infection
… from CD4* Th2 cells. IL-4 and IL-13 induce alternatively activated macrophages (AAMΦ) via their action on the IL-4Rα receptor subunit. AAMΦ are also implicated in numerous other diseases such as fibrosis, allergy, cancer and diabetes.
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Investigation of immune responses in different mouse models of allergic asthma
… of IL-4Ra to the underlying immune response. Alternatively activated macrophages are not necessary for the development of experimental allergic lung inflammation: Development of alternatively activated macrophages (AAM) is induced by signals of IL-4Ra. Alternatively activated macrophages (AAM) …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
… TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are associated with tissue remodelling and the control of exacerbated inflammation. In order to investigate potential roles for IL-4Rá in N. brasiliensis' induced lung pathology, we infected mice …
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Oxime Click-crosslinked Cryogels to Quantify and Target Tumour-associated Macrophage Invasion in Hodgkin Lymphoma
… on targeting malignant cells. Tumour-associated macrophages (TAMs) are associated with poor prognosis and resistance to therapy; however, there remains an unmet need for a suitable pre-clinical model to identify macrophage-targeting therapeutics. We analyzed the HL extracellular matrix (ECM) in …
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Investigation of minor groove binders (MGB), non-ionic surfactant vesicles (NIV) delivery systems and IL-4i1 as novel pathogen- and host-directed drug therapy for tuberculosis
… did not cause DNA damage in murine infected macrophages as displayed by low expression of γ-H2Ax compared to H2O2 and DMSO. Intranasal administration of MGB 364 and MGB-NIV 364 formulation showed one log reduction in bacterial burden with improved pathology and immune cytokine production when …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… both IL-6 and catecholamine secretion from alternatively activated macrophages. In our second study, we demonstrated that WAT browning with its associated lipolysis increased plasma levels of free fatty acids, leading to the accelerated development of hepatic steatosis and dysfunction after …
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
… granuloma response whereby immune cells, mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites. In vitro, these cells and antibodies immobilize, damage/kill worms within the granuloma. This is yet to be confirmed in vivo. We focused on …
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Acute pancreatitis, from local defense to remote organ injury
… complication in the acute pancreatitis. Macrophages are a heterogeneous population based on their anatomical location and their micro-environment. Our data showed an enriched population of CD68+F4/80- macrophages in the lungs of animals with AP. This population had an increased expression …
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Modulation of macrophage function and immune response by a helminth-derived cysteine protease
… immune responses, including the generation of alternatively activated macrophages, regulatory T cells and regulatory B cell populations (Lund et al. in preparation). Nevertheless, the individual molecular components within the ES responsible for these phenomenon are unknown. Therefore, HPLC …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
… fibrosis in chronic lung disease. Additionally, alternatively activated alveolar macrophages (AAMs) expressing ADORA2B, have been implicated in mediating adenosine’s pro-fibrotic effects in IPF. However, the exact role of AAMs in the hypoxic lungs of IPF patients is not known. Our results reveal …