Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"alternative translation"”.
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Alternative mechanisms of translation initiation in modulation of gap junctional coupling
… disease and cancer. The GJA1 mRNA undergoes alternative translation initiation to yield a truncated Cx43 isoform, GJA1-20k, that can regulate gap junction formation. Using epithelial-mesenchymal transition (EMT) as a cellular model of gap junction remodeling, we have demonstrated altered …
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New Roles for the Integrated Stress Response in Cancer and Proteostasis
… limiting total protein synthesis and redirecting translation to stress response transcripts. The ISR has the potential to modify a broad range of processes in cancer, but the major cancer-relevant functions of the pathway have remained elusive due to the complex and redundant nature of the …
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The efficient evaluation of visual queries within a logic-based framework
… This thesis explores issues related to the translation and evaluation of visual queries, including semantic and optimization possibilities. The primary focus will be on the GraphLog query language, defined in the context of the Hy+ visualization system. GraphLog is translated to the …
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Characterization of Peripherin Isoforms in Amyotrophic Lateral Sclerosis
… the presence of an abnormal peripherin alternative splice variant upregulated in ALS. In doing so, we consistently observed the presence of a second peripherin species of ~45 kDa on immunoblots of cell lysates derived from full-length peripherin transfections. Here, we identified this …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… called NF-YAl (long), and NF-YAs (short), which alternative splice exon 3. NF-YAl/NF-YAs ratio changes in different tissues, cell lines and differentiational stages. A robust increase in mRNA levels of NF- YA has been observed in different tumors of epithelial origin, among which BRCA and STAD. …
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A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA
… signal (MLS) surrounded by two potential translation initiation sites (AUG codons) raising the possibility of dual translation initiation sites. Here we demonstrate that Nocturnin is present in the mitochondria and that it exhibits mitochondrial or cytoplasmic localization via the use of …
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PTEN-LONG, a translational variant of the canonical tumor suppressor PTEN
… (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base-pairs upstream of the ATG initiation sequence, adding 173 N-terminal amino acids to the normal PTEN open reading frame. We demonstrate …
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Interrogating annotated protein coding regions for hitherto undetected translation
… non-AUG initiated proteoforms derived via alternative translation start sites that are in-frame with annotated starts. Production of such non-AUG proteoforms can be split into two scenarios. First, some nonAUG proteoforms are generated as alternative proteoforms in addition to annotated …