Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"alternative isoforms"”.
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Towards understanding the mechanisms behind mRNA localisation in growing axons
… that the 5’ untranslated regions (UTRs) of two alternative isoforms of the Acot7 gene generate stark differences in local translation within growing axons. Through in situ hybridization, I demonstrate that these translational profiles result from differences in axonal mRNA localisation. Finally, …
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
… regions are incompletely defined, few alternatively-spliced transcripts are described, and non-coding transcripts remain largely unexplored. mRNA-seq datasets presented in this dissertation define a total of 2.7M introns, most observed at vanishingly low abundance. Using current …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… zinc-fingers protein characterized by multiple alternative isoforms, with important regulatory functions in cell growth and development. The protein Cyclin D1 (CD1), encoded by the CCND1 gene, belongs to the highly conserved cyclin family, whose members function as regulators of CDKs …
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Long-read transcriptome profiling of germinal centre B cells
Alternative splicing (AS) is a major regulatory process underpinning the development and function of the immune system. 29% of alternatively spliced genes are specific to immune cells, yet the regulation and function of AS during B cell activation remain largely unknown. The activation of naive B …